본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Journal of Korean medical science : JKMS v.25 no.7 = no.140, 2010년, pp.1024 - 1028   SCI SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Cox-2 and IL-10 Polymorphisms and Association with Squamous Cell Carcinoma of The Head and Neck in a Korean Sample

Jeong, Seung Won    (Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Hanyang University, Seoul, Korea.   ); Tae, Kyung    (Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Hanyang University, Seoul, Korea.   ); Lee, Seung Hwan    (Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Hanyang University, Seoul, Korea.   ); Kim, Kyung Rae    (Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Hanyang University, Seoul, Korea.   ); Park, Chul Won    (Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Hanyang University, Seoul, Korea.   ); Park, Byung Lae    (Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Korea.   ); Shin, Hyoung Doo    (Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Korea.  );
  • 초록

    Cyclooxygenase-2 (COX-2) is involved in inflammation and carcinogenesis. Interleukin-10 (IL-10) is also regarded as anti-inflammatory factors with the multi-functional ability to positively and negatively influence functional immunity and tumor development. Genetic polymorphisms of COX-2 and IL-10 might contribute to the development of squamous cell carcinoma of the head and neck (SCCHN). The purpose of this study was to evaluate the association of COX-2 and IL-10 single nucleotide polymorphisms (SNPs) with the risk of SCCHN in a Korean sample. We analyzed the COX-2 SNPs, -1329A>G, +1266C>T, and +6365T>C, and the IL-10 SNPs, -1082A>G, +920T>G, and +3917T>C, in 290 Korean SCCHN patients and 358 healthy controls. There was no significant association between the risk of SCCHN and the three COX-2 or three IL-10 SNPs. We analyzed three haplotypes (ht1, ht2, ht3) for COX-2 and found that COX-2 ht3+/+ was associated with a decreased risk of SCCHN in a Korean sample, compared with the COX-2 ht3 -/- genotype ( P = 0.03). Two haplotypes (ht1, ht2) of IL-10 were analyzed and there was no statistical significance in the distribution of haplotypes. Based on these results, the COX-2 haplotype ht3 can be used as a molecular biomarker to predict low risk groups of SCCHN in a Korean sample.


  • 주제어

    Carcinom, Squamous Cell .   Head and Neck Neoplasms .   Cyclooxygenase 2 .   Interleukin-10 .   Polymorphism, Genetic .   Polymorphism, Single Nucleotide.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

유료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기