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Yonsei medical journal v.51 no.5, 2010년, pp.692 - 699   SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Impacts of Cytosolic Phospholipase A2, 15-Prostaglandin Dehydrogenase, and Cyclooxygenase-2 Expressions on Tumor Progression in Colorectal Cancer

Lim, Sung Chul    (Department of Pathology, Chosun University, Gwangju, Korea.   ); Cho, Hoon    (Research Center for Resistant Cells, Chosun University, Gwangju, Korea.   ); Lee, Tae Bum    (Research Center for Resistant Cells, Chosun University, Gwangju, Korea.   ); Choi, Cheol Hee    (Research Center for Resistant Cells, Chosun University, Gwangju, Korea.   ); Min, Young Don    (Department of Surgery, College of Medicine, Chosun University, Gwangju, Korea.   ); Kim, Sung Soo    (Department of Surgery, College of Medicine, Chosun University, Gwangju, Korea.   ); Kim, Kyung Jong    (Department of Surgery, College of Medicine, Chosun University, Gwangju, Korea.  );
  • 초록

    Purpose In addition to cyclooxygenase-2 (COX-2) which is related to prostaglandin E 2 synthesis, other enzymes such as cytosolic phospholipase A2 (cPLA2), microsomal prostaglandin E 2 synthase-1 (mPGES-1), and 15-prostaglandin dehydrogenase (15-PGDH) have been suggested to be related to carcinogenesis of colorectal cancer (CRC). The aim of this study was to investigate the roles of cPLA2, COX-2, mPGES-1, and 15-PGDH in tumor progression. Materials and Methods cPLA2, COX-2, mPGES-1, 15-PGDH, and vascular endothelial growth factor (VEGF) expressions were immunohistochemically examined in 89 CRC, and their expressions were compared with each other or clinicopathologic parameters as well as VEGF as tumor progression parameters. Results cPLA2 was expressed in 54.5%, COX-2 in 80.5%, mPGES-1 in 96.4%, 15-PGDH in 46.1%, and VEGF in 65.9%. The expression of cPLA2 correlated with VEGF expression. COX-2 expression was correlated with the depth of invasion, tumor stage, cPLA2, and VEGF expressions. Moreover, VEGF revealed the highest expression in the tissues positive for both cPLA2 and COX-2. Furthermore, 15-PGDH expression was inversely correlated with VEGF expression. Conclusion The present study demonstrates that cPLA2 and mPGES-1, in addition to COX-2, are constitutively overexpressed, and that 15-PGDH might be attenuated in colorectal cancer. Furthermore, cPLA2 and 15-PGDH as well as COX-2 could have an important role in tumor progression.


  • 주제어

    cPLA2 .   COX-2 .   mPGES-1 .   15-PGDH .   colorectal cancer.  

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