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ACS applied materials & interfaces v.9 no.2, 2017년, pp.1263 - 1272   SCI SCIE
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PB@Au Core–Satellite Multifunctional Nanotheranostics for Magnetic Resonance and Computed Tomography Imaging in Vivo and Synergetic Photothermal and Radiosensitive Therapy

Dou, Yan (School of Life Sciences, School of Material Science and Engineering, Tianjin University, Tianjin Engineering Center for Micro-Nano Biomaterials and Detection-Treatment Technology, Tianjin 300072, ) ; Li, Xue (Department of Radiation Oncology and Department of Radiology, The Second Hospital of Tianjin Medical University, Tianjin 300211, ) ; Yang, Weitao (School of Life Sciences, School of Material Science and Engineering, Tianjin University, Tianjin Engineering Center for Micro-Nano Biomaterials and Detection-Treatment Technology, Tianjin 300072, ) ; Guo, Yanyan (Department of Radiation Oncology and Department of Radiology, The Second Hospital of Tianjin Medical University, Tianjin 300211, ) ; Wu, Menglin (Department of Radiation Oncology and Department of Radiology, The Second Hospital of Tianjin Medical University, Tianjin 300211, ) ; Liu, Yajuan (School of Life Sciences, School of Material Science and Engineering, Tianjin University, Tianjin Engineering Center for Micro-Nano Biomaterials and Detection-Treatment Technology, Tianjin 300072, ) ; Li, Xiaodong (Department of ) ; Zhang, Xuening ; Chang, Jin ;
  • 초록  

    To integrate multiple diagnostic and therapeutic strategies on a single particle through simple and effective methods is still challenging for nanotheranostics. Herein, we develop multifunctional nanotheranostic PB@Au core–satellite nanoparticles (CSNPs) based on Prussian blue nanoparticles (PBNPs) and gold nanoparticles (AuNPs), which are two kinds of intrinsic theranostic nanomaterials, for magnetic resonance (MR)–computed tomography (CT) imaging and synergistic photothermal and radiosensitive therapy (PTT– RT ). PBNPs as cores enable T 1 - and T 2 -weighted MR contrast and strong photothermal effect, while AuNPs as satellites offer CT enhancement and radiosensitization. As revealed by both MR and CT imaging, CSNPs realized efficient tumor localization by passively targeted accumulation after intravenous injection. In vivo studies showed that CSNPs resulted in synergistic PTT– RT action to achieve almost entirely suppression of tumor growth without observable recurrence. Moreover, no obvious systemic toxicity of mice confirmed good biocompatibility of CSNPs. These results raise new possibilities for clinical nanotheranostics with multimodal diagnostic and therapeutic coalescent design. Graphic Abstract ACS Electronic Supporting Info


  • 주제어

    nanotheranostics .   prussian blue nanoparticles .   gold nanoparticles .   multimodal imaging .   synergistic therapy.  

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