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ACS applied materials & interfaces v.9 no.2, 2017년, pp.1293 - 1304   SCI SCIE
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Additively Manufactured and Surface Biofunctionalized Porous Nitinol

Gorgin Karaji, Z. (Department of Mechanical Engineering, Kermanshah University of Technology, 63766-67178 Kermanshah, ) ; Speirs, M. (PMA Division, Department of Mechanical Engineering, KU Leuven, 3001 Leuven, ) ; Dadbakhsh, S. (PMA Division, Department of Mechanical Engineering, KU Leuven, 3001 Leuven, ) ; Kruth, J.-P. (PMA Division, Department of Mechanical Engineering, KU Leuven, 3001 Leuven, ) ; Weinans, H. (Department of Biomechanical Engineering, Delft University of Technology, 2628 CD Delft, ) ; Zadpoor, A. A. (Department of Biomechanical Engineering, Delft University of Technology, 2628 CD Delft, ) ; Amin Yavari, S. (Department of Biomechanical Engineering, Delft University of Technology, 2628 CD Delft, ) ;
  • 초록  

    Enhanced bone tissue regeneration and improved osseointegration are among the most important goals in design of multifunctional orthopedic biomaterials. In this study, we used additive manufacturing (selective laser melting) to develop multifunctional porous nitinol that combines superelasticity with a rationally designed microarchitecture and biofunctionalized surface. The rational design based on triply periodic minimal surfaces aimed to properly adjust the pore size, increase the surface area (thereby amplifying the effects of surface biofunctionalization), and resemble the curvature characteristics of trabecular bone. The surface of additively manufactured (AM) porous nitinol was biofunctionalized using polydopamine-immobilized rhBMP2 for better control of the release kinetics. The actual morphological properties of porous nitinol measured by microcomputed tomography (e.g., open/close porosity, and surface area) closely matched the design values. The superelasticity originated from the austenite phase formed in the nitinol porous structure at room temperature. Polydopamine and rhBMP2 signature peaks were confirmed by X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy tests. The release of rhBMP2 continued until 28 days. The early time and long-term release profiles were found to be adjustable independent of each other. In vitro cell culture showed improved cell attachment, cell proliferation, cell morphology (spreading, spindle-like shape), and cell coverage as well as elevated levels of ALP activity and increased calcium content for biofunctionalized surfaces as compared to as-manufactured specimens. The demonstrated functionalities of porous nitinol could be used as a basis for deployable orthopedic implants with rationally designed microarchitectures that maximize bone tissue regeneration performance by release of biomolecules with adjustable and well-controlled release profiles. Graphic Abstract


  • 주제어

    shape memory alloys .   additive manufacturing .   biomimetic topology .   osteogenic coatings .   controlled release.  

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