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ACS applied materials & interfaces v.9 no.2, 2017년, pp.1384 - 1394   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Bioengineered Osteoinductive Broussonetia kazinoki/Silk Fibroin Composite Scaffolds for Bone Tissue Regeneration

Kim, Do Kyung (Department of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer BIN Research Center, Chonbuk National University, Deokjin-gu, Jeonju 561-756, ); Kim, Jeong In ( Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, ); Hwang, Tae In ( Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju 561-756, ); Sim, Bo Ra ( Department of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer BIN Research Center, Chonbuk National University, Deokjin-gu, Jeonju 561-756, ); Khang, Gilson ( Department of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer BIN Research Center, Chonbuk National University, Deokjin-gu, Jeonju 561-756, );
  • 초록  

    In this article, Broussonetia kazinoki (BK) powdery extract is utilized to modify the silk fibroin (SF) scaffold and applied to the bone defect area. The BK/SF scaffold is an efficient cell carrier which promotes cell proliferation and osteogenic differentiation of rBMSCs (bone marrow derived mesenchymal stem cells). We confirmed biocompatibility and osteogenic differentiation capacity of BK/SF scaffolds compared to pristine. SF scaffold in both in vitro and in vivo evaluation. Gene expression related to osteogenic differentiation and bone regeneration significantly upregulated in the BK/SF scaffold group. The implanted scaffolds were attached well to the surface of the bone defect region and integrated with surrounding tissues without significant inflammatory reaction. Furthermore, almost 45% of bone volume has been recovered at 8 weeks postsurgery, while the SF and control group showed 20% recovery. These results suggest that BK powdery extract incorporated with an SF scaffold might be a suitable substitute for an alternative bone graft for bone regeneration.


  • 주제어

    plant extract .   Broussonetia kazinoki .   silk fibroin .   bone regeneration .   scaffold.  

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