본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

ACS applied materials & interfaces v.9 no.2, 2017년, pp.1247 - 1254   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Molecular Dynamics Simulation and Experimental Studies of Gold Nanoparticle Templated HDL-like Nanoparticles for Cholesterol Metabolism Therapeutics

Lai, Cheng-Tsung (Department of Chemistry, Northwestern University, Evanston, Illinois 60208, ); Sun, Wangqiang (Department of Urology, Northwestern University, Chicago, Illinois 60611, ); Palekar, Rohun U. (Department of Urology, Northwestern University, Chicago, Illinois 60611, ); Thaxton, C. Shad (Department of Urology, Northwestern University, Chicago, Illinois 60611, ); Schatz, George C. (Department of Chemistry, Northwestern University, Evanston, Illinois 60208, );
  • 초록  

    High-density lipoprotein (HDL) plays an important role in the transport and metabolism of cholesterol. Mimics of HDL are being explored as potentially powerful therapeutic agents for removing excess cholesterol from arterial plaques. Gold nanoparticles (AuNPs) functionalized with apolipoprotein A-I and with the lipids 1,2-dipalmitoyl- sn -glycero-3-phosphocholine and 1,2-dipalmitoyl- sn -glycero-3-phosphoethanolamine-N-[3-(2-pyridyldithio)propionate] have been demonstrated to be robust acceptors of cellular cholesterol. However, detailed structural information about this functionalized HDL AuNP is still lacking. In this study, we have used X-ray photoelectron spectroscopy and lecithin/cholesterol acyltransferase activation experiments together with coarse-grained and all-atom molecular dynamics simulations to model the structure and cholesterol uptake properties of the HDL AuNP construct. By simulating different apolipoprotein-loaded AuNPs, we find that lipids are oriented differently in regions with and without apoA-I. We also show that in this functionalized HDL AuNP, the distribution of cholesteryl ester maintains a reverse concentration gradient that is similar to the gradient found in native HDL. Graphic Abstract ACS Electronic Supporting Info


  • 주제어

    apolipoprotein A-I .   HDL .   gold nanoparticle .   cholesterol .   cholesteryl ester .   LCAT.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기