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ACS applied materials & interfaces v.9 no.2, 2017년, pp.1219 - 1225   SCI SCIE
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Worm-Like Superparamagnetic Nanoparticle Clusters for Enhanced Adhesion and Magnetic Resonance Relaxivity

Smith, Cartney E. (Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, ); Lee, JuYeon (Department of Chemistry, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, ); Seo, Yongbeom (Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, ); Clay, Nicholas (Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, ); Park, Jooyeon (Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, ); Shkumatov, Artem (Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, ); Ernenwein, Dawn (Department of Chemistry, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, ); Lai, Mei-Hsiu (Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, ); Misra, Sanjay (Departmen ); Sing, Charles E. ( ); Andrade, Brenda ( ); Zimmerman, Steven C. ( ); Kong, Hyunjoon ( );
  • 초록  

    Nanosized bioprobes that can highlight diseased tissue can be powerful diagnostic tools. However, a major unmet need is a tool with adequate adhesive properties and contrast-to-dose ratio. To this end, this study demonstrates that targeted superparamagnetic nanoprobes engineered to present a worm-like shape and hydrophilic packaging enhance both adhesion efficiency to target substrates and magnetic resonance (MR) sensitivity. These nanoprobes were prepared by the controlled self-assembly of superparamagnetic iron oxide nanoparticles (SPIONs) into worm-like superstructures using glycogen-like amphiphilic hyperbranched polyglycerols functionalized with peptides capable of binding to defective vasculature. The resulting worm-like SPION clusters presented binding affinity to the target substrate 10-fold higher than that of spherical ones and T 2 molar MR relaxivity 3.5-fold higher than that of conventional, single SPIONs. The design principles discovered for these nanoprobes should be applicable to a range of other diseases where improved diagnostics are needed. Graphic Abstract ACS Electronic Supporting Info


  • 주제어

    magnetic resonance imaging .   nonspherical nanoparticle cluster .   superparamagnetic iron oxide nanoparticle .   hyperbranched polyglycerol .   targeted imaging.  

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