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Analytical chemistry v.89 no.2, 2017년, pp.1110 - 1116   SCI SCIE
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Single Nanochannel Platform for Detecting Chiral Drugs

Boussouar, Imene (Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, ); Chen, Qianjin ( Department of Chemistry, University of Utah, 315 S, 1400 E, Salt Lake City, Utah 84112, ); Chen, Xue ( Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, ); Zhang, Yulun ( Department of Chemistry, University of Utah, 315 S, 1400 E, Salt Lake City, Utah 84112, ); Zhang, Fan ( Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, ); Tian, Demei ( Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, ); White, Henry S. ( Department of Chemistry, University of Utah, 315 S, 1400 E, Salt Lake City, Utah 84112, ); Li, Haibing ( Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal Uni );
  • 초록  

    Chiral drugs play an essential role in medical and biochemical systems, and thus enantioselective analysis of chiral molecules has become a central focus in chemical, biological, medical, and pharmaceutical research. The design of chiral drug-detecting systems is a long-term and challenging task. Here we report the use of a modification-free nanochannel method for enantioselective recognition of S -naproxen from R -naproxen using N -acetyl- l -cysteine-capped gold nanoparticles as a chiral selector. The chiral discrimination is based on a drug-induced nanoparticle diastereoselective aggregation mechanism that blocks ion transport through the nanochannel. We demonstrated that high S -Npx selectivity in both water and biological samples can be achieved. This simple method has potential applications as a general platform for the detection of chiral molecules. Graphic Abstract ACS Electronic Supporting Info


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