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Bioconjugate chemistry v.28 no.1, 2017년, pp.115 - 123   SCI SCIE
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Recent Advances in Inorganic Nanoparticle-Based NIR Luminescence Imaging: Semiconductor Nanoparticles and Lanthanide Nanoparticles

Kim, Dokyoon (Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, ); Lee, Nohyun ( School of Advanced Materials Engineering, Kookmin University, Seoul 02707, ); Park, Yong Il ( School of Chemical Engineering, Chonnam National University, Gwangju 61186, ); Hyeon, Taeghwan ( Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, );
  • 초록  

    Several types of nanoparticle-based imaging probes have been developed to replace conventional luminescent probes. For luminescence imaging, near-infrared (NIR) probes are useful in that they allow deep tissue penetration and high spatial resolution as a result of reduced light absorption/scattering and negligible autofluorescence in biological media. They rely on either an anti-Stokes or a Stokes shift process to generate luminescence. For example, transition metal-doped semiconductor nanoparticles and lanthanide-doped inorganic nanoparticles have been demonstrated as anti-Stokes shift-based agents that absorb NIR light through two- or three-photon absorption process and upconversion process, respectively. On the other hand, quantum dots (QDs) and lanthanide-doped nanoparticles that emit in NIR-II range (similar to 1000 to similar to 1350 nm) were suggested as promising Stokes shift-based imaging agents. In this topical review, we summarize and discuss the recent progress in the development of inorganic nanoparticle-based luminescence imaging probes working in NIR range.


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