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Advanced functional materials v.27 no.4, 2017년, pp. -    SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

A Mineralized High Strength and Tough Hydrogel for Skull Bone Regeneration

Xu, Bing (School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300354, P. R. China ); Zheng, Pengbin (Tianjin First Center Hospital, Tianjin, 300192, P. R. China ); Gao, Fei (School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300354, P. R. China ); Wang, Wei (School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300354, P. R. China ); Zhang, Hongtao (Tianjin First Center Hospital, Tianjin, 300192, P. R. China ); Zhang, Xuran (Tianjin First Center Hospital, Tianjin, 300192, P. R. China ); Feng, Xuequan ( ); Liu, Wenguang ( );
  • 초록  

    Over the past decade, high strength hydrogels have been intensively investigated. However, developing high strength biofunctional hydrogels for eliciting bone regeneration has been rarely reported. In this work, a mineralized high strength and tough hydrogel is synthesized by one‐step copolymerization of acrylonitrile, 1‐vinylimidazole, and polyethylene glycol diacrylate, followed by in situ precipitation mineralization. It is demonstrated that the CNCN dipole–dipole pairings combined with the interaction of CaP nanocrystals with polymer chains contribute to tremendous increase of tensile/compressive strength, modulus, and fracture energy up to 6.1 MPa, 11.5 MPa, 6.47 MPa, and 7935 J m −2 , respectively. The biomineralization is shown to facilitate the attachment and proliferation of C2C12 cells in vitro. This biomineralized hydrogel scaffold is implanted into an 8 mm diameter critical‐size of calvarial defect of rats to evaluate the bone regeneration. 12 week postsurgery results reveal that the mineralized hydrogel exhibits the highest bone volume and density within the defect as measured by computed tomography and histology. This mineralized high strength and tough hydrogel offers a broad range of possibilities to be developed as biofunctional scaffold to promote the reconstruction and regeneration of not only bone, but also load‐bearing connective tissue.


  • 주제어

    bone regeneration .   high strength .   hydrogels .   mineralization.  

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