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Annals of neurology v.81 no.1, 2017년, pp.147 - 151   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Cerebral white matter abnormalities in patients with charcot‐marie‐tooth disease

Lee, Mina (Department of Neurology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul, South Korea ); Park, Chang-hyun (Department of Neurology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul, South Korea ); Chung, Hwa‐Kyung (Department of Neurology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul, South Korea ); Kim, Hyeon Jin (Department of Neurology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul, South Korea ); Choi, Yunseo (Department of Neurology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul, South Korea ); Yoo, Jeong Hyun (Department of Radiology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul, South Korea ); Yoon, Young Chul (Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea ); Hong, Young Bin (Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea ); Chung, Ki Wha (Department of Biologic ); Choi, Byung‐Ok ( ); Lee, Hyang Woon ( );
  • 초록  

    Here, we report the structural evidence of cerebral white matter abnormalities in Charcot-Marie-Tooth (CMT) patients and the relationship between these abnormalities and clinical disability. Brain diffusion tensor imaging (DTI) was performed in CMT patients with demyelinating (CMT1A/CMT1E), axonal (CMT2A/CMT2E), or intermediate (CMTX1/DI-CMT) peripheral neuropathy. Although all patients had normal brain magnetic resonance imaging, all genetic subgroups except CMT1A had abnormal DTI findings indicative of significant cerebral white matter abnormalities: decreased fractional anisotropy and axial diffusivity, and increased radial diffusivity. DTI abnormalities were correlated with clinical disability, suggesting that there is comorbidity of central nervous system damage with peripheral neuropathy in CMT patients. ANN NEUROL 2017;81:147-151


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