Efficacy of a Rhealba® Oat Extract‐based emollient on chronic pruritus in elderly French outpatients
Abstract Background Chronic pruritus, defined as itch persisting more than 6 weeks, is a debilitating problem that affects one in four elderly adults. Emollients are recommended for the management of pruritus, but evidence of efficacy is scarce. Objective Assess the efficacy of a Rhealba ? Oat Extract‐based emollient in the management of chronic pruritus in elderly outpatients. Methods This was a randomized, mono‐centric, open‐label, cross‐over study in adults ≥60 years of age with xerosis associated with chronic pruritus. Subjects were randomized 1:1 to start with a 2‐week non‐treatment phase or a 2‐week treatment phase in which they applied the emollient once or twice daily. The primary outcome was subject‐assessed pruritus using an established visual analogue scale. Subjects also assessed pruritus using the 5‐D itch scale. Investigators assessed xerosis using the Overall Dry Skin Score and measured hydration index by Corneometer ? , desquamation by D‐Squame and transepidermal water loss by Aquaflux ? . Results Thirty subjects were included. Pruritus intensity on the visual analogue scale improved significantly more during the treatment phase than during the non‐treatment phase ( P P P = 0.0042). At the end of the treatment phase, more than half of the subjects reported an improvement in pruritus, and 30% reported complete disappearance, whereas pruritus remained stable during the non‐treatment phase ( P P Conclusion Daily use of a Rhealba Oat Extract‐based emollient can provide relief to elderly adults who suffer from xerosis associated with chronic pruritus.
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