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Journal of the American Geriatrics Society v.65 no.1, 2017년, pp.179 - 184   SCI SCIE SSCI
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Factors Influencing Transitions Between Frailty States in Elderly Adults: The Progetto Veneto Anziani Longitudinal Study

Trevisan, Caterina (Geriatrics Division, Department of Medicine, University of Padova, Padova, Italy ); Veronese, Nicola ( Aging Branch, Institute of Neuroscience, National Research Council, Padova, Italy ); Maggi, Stefania ( Internal Medicine Division, Azienda Ospedaliera, Padova, Italy ); Baggio, Giovannella ( Geriatrics Division, Department of Medicine, University of Padova, Padova, Italy ); Toffanello, Elena Debora ( Aging Branch, Institute of Neuroscience, National Research Council, Padova, Italy ); Zambon, Sabina ( Clinica Medica I, Department of Medicine, University of Padova, Padova, Italy ); Sartori, Leonardo ( Internal Medicine Division, Azienda Ospedaliera, Padova, Italy ); Musacchio, Estella ( Biostatistics, Epidemiology and Public Health Unit, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy ); Perissinotto, Egle ( Aging Branch, Institute of Neuroscience, National Research Council, Padova, Italy ); Crepaldi, Gaetano ( Geriatrics Division, Department of Medicine, University of Padova, Padova, Italy ); Manzato, Enzo ( Geriatrics Division, Department of Medicine, University of Padova, Padova, Italy ); Sergi, Giuseppe ( );
  • 초록  

    Objectives To investigate frailty state transitions in a cohort of older Italian adults to identify factors exacerbating or improving frailty conditions. Design Population‐based longitudinal study with mean follow‐up of 4.4 years. Setting Community. Participants Individuals enrolled in the Progetto Veneto Anziani (Pro.V.A.) (N = 2,925; n = 1,179 male, n = 1,746 female; mean age 74.4 ± 7.3). Measurements Frailty was identified at baseline and follow‐up based on the presence of at least three Fried criteria; prefrailty was defined as the presence of one or two Fried criteria. Anthropometric, socioeconomic, and clinical characteristics were assessed at baseline in a personal interview and clinical examination using validated scales and medical history. Results During the study period, 1,114 (38.1%) subjects retained their baseline frailty status, 1,066 (36.4%) had a transition in frailty status, and the remainder of the sample died. Older age, female sex, obesity, cardiovascular disease, osteoarthritis, smoking, loss of vision, low levels of self‐sufficiency and physical performance, cognitive impairment, hypovitaminosis D, hyperuricemia, and polypharmacy were associated with increasing frailty and greater mortality. Conversely, overweight, low to moderate drinking, high educational level, and living alone were associated with decreasing frailty. Conclusions Frailty was confirmed as a dynamic syndrome, with socioeconomic and clinical factors that could be targets of preventive actions influencing transitions to better or worse frailty status.


  • 주제어

    frailty .   elderly .   risk factors.  

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