본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology v.46 no.2, 2017년, pp.142 - 147   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

The therapeutic effects of apigenin and dexamethasone on 5‐fluorouracil‐induced oral mucositis – a pilot study using a Syrian hamster model

Molina Prats, Patricia (Department of Oral Medicine, Ageing Research Institute, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain ); Gómez Garcia, Francisco (Pathologic Anatomy, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain ); Martinez Diaz, Francisco (Pathologic Anatomy, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain ); Amaral Mendes, Rui (Department of Oral and Maxillofacial Medicine and Diagnostic Sciences, Case Western Reserve University, Cleveland, OH, USA ); Lopez‐ ( ); Jornet, Pia ( );
  • 초록  

    Objective Oral mucositis (OM) is a common complication of chemotherapy and radiotherapy. The aim of this study was to evaluate the effects of treating 5‐fluorouracil‐induced OM with apigenin and dexamethasone. Methods Thirty‐six male Syrian hamsters were randomly assigned to one of three groups: control (50% acetic acid + 5‐FU), 50% acetic acid + 5‐FU + potassium Apigenin (KA), and 50% acetic acid + 5‐FU + dexamethasone. The animals from each group were sacrificed 5, 7, 10, and 14 days after inducing the mucositis, and two samples collected from each animal, accounting a total of 72 samples. Macroscopic changes were assessed by histomorphometric analysis, with ulcers being assessed by imaging analysis and the number of inflammatory cells in the ulcerated region quantified in all periods through histomorphometric analysis (H&E). Furthermore, immunohistochemical changes were evaluated by proliferating cell nuclear antigen. Results All groups presented an increased inflammatory infiltrate after 7 days, compared to other evaluation times ( P ≥ 0.05). There was significant difference between apigenin and control group in the 10‐days period. Lower quantity of inflammatory cells in the apigenin‐treated group in comparison with control group in the 7‐ and 10‐days periods was observed ( P Conclusions Apigenin treatment may enhance healing of OM induced by 5‐fluorouracil, thus suggesting that more extensive research in this area may be useful to assess the role of agents of natural origin capable of preventing OM. Hence, further studies involving broader samples are need to confirm the therapeutic potential shown by this study.


  • 주제어

    apigenin .   dexamethasone .   oral mucositis .   Syrian golden hamster.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기