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Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology v.46 no.2, 2017년, pp.98 - 105   SCI SCIE
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MALAT1 induces tongue cancer cells' EMT and inhibits apoptosis through Wnt/β‐catenin signaling pathway

Liang, Jun (Department of Oral and Maxillofacial Surgery, Fifth Affiliated Hospital of Sun Yat‐sen University, Zhuhai, China ) ; Liang, Lizhong (Department of Oral and Maxillofacial Surgery, Fifth Affiliated Hospital of Sun Yat‐sen University, Zhuhai, China ) ; Ouyang, Kexiong (Department of Oral and Maxillofacial Surgery, Stomatological Hospital of Guangzhou Medical University, Guangzhou, China ) ; Li, Zhiqiang (Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Southern Medical University & Guangdong Provincial Stomatological Hospital, Guangzhou, China ) ; Yi, Xianping (Department of Pathology, Fifth Affiliated Hospital of Sun Yat‐sen University, Zhuhai, China ) ;
  • 초록  

    Background MALAT1 is recognized as an oncogenic lncRNA in various malignancies. However, its expression and function in oral tongue squamous cell carcinoma are still unknown. This study aims to investigate the expression and function of MALAT1 in TSCC tissues and cells. Materials and Methods qPCR was performed to detect the expression of MALAT1. MALAT1 was suppressed and upregulated by plasmid transfection in TSCC cells, and then cell migration, invasion, EMT, and apoptosis were analyzed. Results LncRNA MALAT1 was upregulated in TSCC tissues and correlated with cervical lymph node metastasis in TSCC patients. Moreover, MALAT1 induced cell migration, invasion, EMT, and inhibited apoptosis by modulating Wnt/β‐catenin signaling pathway. Finally, inhibiting Wnt/β‐catenin signaling pathway attenuated the effect of exogenous MALAT1. Conclusion In summary, upregulated MALAT1 in TSCC promoted EMT and inhibited cell apoptosis by modulating Wnt/β‐catenin signaling pathway.


  • 주제어

    epithelial‐to‐mesenchymal transition .   invasion .   MALAT1 .   migration .   tongue squamous cell carcinoma.  

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