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Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology v.46 no.2, 2017년, pp.154 - 160   SCI SCIE
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Natural products for the management of xerostomia: a randomized, double‐blinded, placebo‐controlled clinical trial

Navarro Morante, Anabel (Department of Oral Medicine, Ageing Research Institute, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain ); Wolff, Andy (Saliwell Ltd., Harutzim, Israel ); Bautista Mendoza, Gloria Rocio (University of El Bosque, Bogotá, Colombia ); López‐Jornet, Pia ( );
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    Aim The aim of this study was to evaluate the clinical performance of lycopene‐enriched virgin olive oil in spray form used to treat patients with drug‐induced xerostomia, comparing this with a placebo spray. Materials and Methods This double‐blind, randomized clinical trial included elderly subjects with drug‐induced xerostomia ( n = 60). Resting salivary flow was measured using the draining technique. The Xerostomia Inventory (XI) was used to assess symptoms and the Oral Health Impact Profile 14 (OHIP‐14) to assess patient quality of life. Evaluations were made before and after 12 weeks of product/placebo application. Results Sixty patients took part in the study. Symptoms improved among the treatment group ( n = 30) after 12 weeks in the following XI domains: ‘Rate the difficulty you experience in speaking because of dryness’ ( P = 0.03); ‘Rate how much saliva is in your mouth’ ( P = 0.03); and ‘Rate the dryness of your lips’ ( P = 0.04). The placebo group ( n = 30) underwent improvements in: ‘Rate how much saliva is in your mouth’ ( P = 0.02) and ‘Rate the dryness of your mouth’ ( P = 0.01). A significant improvement ( P = 0.001) in oral‐related quality of life (OHIP‐14) was identified in the treatment group, while no significant differences were observed in the placebo group ( P > 0.05). Conclusion The topical application of lycopene‐enriched virgin olive oil and its placebo counterpart improved xerostomia‐related symptoms significantly (but not salivary flow rate) in patients with drug‐induced xerostomia.


  • 주제어

    dry mouth .   lycopene .   quality of life .   saliva .   topical application .   xerostomia.  

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