본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Journal of viral hepatitis v.24 no.3, 2017년, pp.187 - 196   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Chronic hepatitis C infection and liver disease in HIV‐coinfected patients in Asia

Durier, N. (Cipto Mangunkusumo General Hospital, Jakarta, Indonesia ); Yunihastuti, E. (HIVNAT, the Thai Red Cross AIDS Research Centre, Bangkok, Thailand ); Ruxrungtham, K. (National Hospital of Tropical Diseases, Hanoi, Vietnam ); Kinh, N. V. (University of Malaya Medical Centre, Kuala Lumpur, Malaysia ); Kamarulzaman, A. (The Kirby Institute, UNSW Australia, Sydney, NSW, Australia ); Boettiger, D. (Cipto Mangunkusumo General Hospital, Jakarta, Indonesia ); Widhani, A. (HIVNAT, the Thai Red Cross AIDS Research Centre, Bangkok, Thailand ); Avihingsanon, A. (National Hospital of Tropical Diseases, Hanoi, Vietnam ); Huy, B. V. (University of Malaya Medical Centre, Kuala Lumpur, Malaysia ); Syed Omar, S. F. B. (Cipto Mangunkusumo General Hospital, Jakarta, Indonesia ); Sanityoso, A. (Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand ); Chittmittrapap, S. (National Hospital of Tropical Diseases, Hanoi, Vietnam ); Dung, N. T. H. (Faculty of Medicine, Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, Malaysia ); Pillai, V. (TREAT Asia, amfAR ‐ ); Suwan‐Ampai, T. (The Foundation for AIDS Research, Bangkok, Thailand ); Law, M. (The Kirby Institute, UNSW Australia, Sydney, NSW, Australia ); Sohn, A. H. (TR ); Matthews, G. ( );
  • 초록  

    Summary Data on markers of hepatitis C virus (HCV) disease in HIV‐HCV‐coinfected patients in resource‐limited settings are scarce. We assessed HCV RNA, HCV genotype (GT), IL28B GT and liver fibrosis (FibroScan ? ) in 480 HIV‐infected patients with positive HCV antibody in four HIV treatment centres in South‐East Asia. We enrolled 165 (34.4%) patients in Jakarta, 158 (32.9%) in Bangkok, 110 (22.9%) in Hanoi and 47 (9.8%) in Kuala Lumpur. Overall, 426 (88.8%) were male, the median (IQR) age was 38.1 (34.7‐42.5) years, 365 (76.0%) reported HCV exposure through injecting drug use, and 453 (94.4%) were on combination antiretroviral therapy. The median (IQR) CD4 count was 446 (325‐614) cells/mm 3 and 208 (94.1%) of 221 patients tested had HIV‐1 RNA 10 IU/mL. Among 380 patients with HCV GT, 223 (58.7%) had GT1, 97 (25.5%) had GT3, 43 (11.3%) had GT6, eight (2.1%) had GT4, two (0.5%) had GT2, and seven (1.8%) had indeterminate GT. Of 222 patients with IL28B testing, 189 (85.1%) had rs12979860 CC genotype, and 199 (89.6%) had rs8099917 TT genotype. Of 380 patients with FibroScan ? , 143 (37.6%) had no/mild liver fibrosis (F0‐F1), 83 (21.8%) had moderate fibrosis (F2), 74 (19.5%) had severe fibrosis (F3), and 79 (20.8%) had cirrhosis (F4). One patient (0.3%) had FibroScan ? failure. In conclusion, a high proportion of HIV‐HCV‐coinfected patients had chronic HCV infection. HCV GT1 was predominant, and 62% of patients had liver disease warranting prompt treatment (≥F2).


  • 주제어

    Asia .   chronic infection .   fibrosis .   hepatitis C virus .   HIV.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기