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Journal of viral hepatitis v.24 no.3, 2017년, pp.187 - 196   SCI SCIE
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Chronic hepatitis C infection and liver disease in HIV‐coinfected patients in Asia

Durier, N. (Cipto Mangunkusumo General Hospital, Jakarta, Indonesia ); Yunihastuti, E. ( HIVNAT, the Thai Red Cross AIDS Research Centre, Bangkok, Thailand ); Ruxrungtham, K. ( National Hospital of Tropical Diseases, Hanoi, Vietnam ); Kinh, N. V. ( University of Malaya Medical Centre, Kuala Lumpur, Malaysia ); Kamarulzaman, A. ( The Kirby Institute, UNSW Australia, Sydney, NSW, Australia ); Boettiger, D. ( Cipto Mangunkusumo General Hospital, Jakarta, Indonesia ); Widhani, A. ( HIVNAT, the Thai Red Cross AIDS Research Centre, Bangkok, Thailand ); Avihingsanon, A. ( National Hospital of Tropical Diseases, Hanoi, Vietnam ); Huy, B. V. ( University of Malaya Medical Centre, Kuala Lumpur, Malaysia ); Syed Omar, S. F. B. ( Cipto Mangunkusumo General Hospital, Jakarta, Indonesia ); Sanityoso, A. ( Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand ); Chittmittrapap, S. ( National Hospital of Tropical Diseases, Hanoi, Vietnam ); Dung, N. T. H. ( Faculty of Medicine, Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, Malaysia ); Pillai, V. ( TREAT Asia, amfAR ‐ ); Suwan‐ ( The Foundation for AIDS Research, Bangkok, Thailand ); Ampai, T. ( The Kirby Institute, UNSW Australia, Sydney, NSW, Australia ); Law, M. ( TR ); Sohn, A. H. ( ); Matthews, G. ( );
  • 초록  

    Summary Data on markers of hepatitis C virus (HCV) disease in HIV‐HCV‐coinfected patients in resource‐limited settings are scarce. We assessed HCV RNA, HCV genotype (GT), IL28B GT and liver fibrosis (FibroScan ? ) in 480 HIV‐infected patients with positive HCV antibody in four HIV treatment centres in South‐East Asia. We enrolled 165 (34.4%) patients in Jakarta, 158 (32.9%) in Bangkok, 110 (22.9%) in Hanoi and 47 (9.8%) in Kuala Lumpur. Overall, 426 (88.8%) were male, the median (IQR) age was 38.1 (34.7‐42.5) years, 365 (76.0%) reported HCV exposure through injecting drug use, and 453 (94.4%) were on combination antiretroviral therapy. The median (IQR) CD4 count was 446 (325‐614) cells/mm 3 and 208 (94.1%) of 221 patients tested had HIV‐1 RNA 10 IU/mL. Among 380 patients with HCV GT, 223 (58.7%) had GT1, 97 (25.5%) had GT3, 43 (11.3%) had GT6, eight (2.1%) had GT4, two (0.5%) had GT2, and seven (1.8%) had indeterminate GT. Of 222 patients with IL28B testing, 189 (85.1%) had rs12979860 CC genotype, and 199 (89.6%) had rs8099917 TT genotype. Of 380 patients with FibroScan ? , 143 (37.6%) had no/mild liver fibrosis (F0‐F1), 83 (21.8%) had moderate fibrosis (F2), 74 (19.5%) had severe fibrosis (F3), and 79 (20.8%) had cirrhosis (F4). One patient (0.3%) had FibroScan ? failure. In conclusion, a high proportion of HIV‐HCV‐coinfected patients had chronic HCV infection. HCV GT1 was predominant, and 62% of patients had liver disease warranting prompt treatment (≥F2).


  • 주제어

    Asia .   chronic infection .   fibrosis .   hepatitis C virus .   HIV.  

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