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Infection and immunity v.85 no.2, 2017년, pp.e00806-16 - e00806-16   SCI SCIE
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Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22

Porte, Rémi (Univ. Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR8204, CIIL–Center for Infection and Immunity of Lille, Lille, France ) ; Van Maele, Laurye (Univ. Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR8204, CIIL–Center for Infection and Immunity of Lille, Lille, France ) ; Muéñoz-Wolf, Natalia (Laboratory for Vaccine Research, Department of Biotechnology, Instituto de Higiene, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay ) ; Folignéñé, Benoit (Univ. Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR8204, CIIL–Center for Infection and Immunity of Lille, Lille, France ) ; Dumoutier, Laure (Ludwig Institute for Cancer Research, Brussels Branch, and de Duve Institute, Universitéñééé ) ; Tabareau, Julien (Catholique de Louvain, Brussels, Belgium ) ; Cayet, Delphine (Univ. Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR8204, CIIL–Center for Infection and Immunity of Lille, Lille, France ) ; Gosset, Pierre (Univ. Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, ) ; Jonckheere, Nicolas ; Van Seuningen, Isabelle ; Chabalgoity, Joséñéé ; A. ; Simonet, Michel ; Lamkanfi, Mohamed ; Renauld, Jean-Christophe ; Sirard, Jean-Claude ; Carnoy, Christophe ;
  • 초록  

    Signaling through Toll-like receptors (TLRs), the main receptors in innate immunity, is essential for the defense of mucosal surfaces. It was previously shown that systemic TLR5 stimulation by bacterial flagellin induces an immediate, transient interleukin-22 (IL-22)-dependent antimicrobial response to bacterial or viral infections of the mucosa. This process was dependent on the activation of type 3 innate lymphoid cells (ILCs). The objective of the present study was to analyze the effects of flagellin treatment in a murine model of oral infection with Yersinia pseudotuberculosis (an invasive, Gram-negative, enteropathogenic bacterium that targets the small intestine). We found that systemic administration of flagellin significantly increased the survival rate after intestinal infection (but not systemic infection) by Y. pseudotuberculosis . This protection was associated with a low bacterial count in the gut and the spleen. In contrast, no protection was afforded by administration of the TLR4 agonist lipopolysaccharide, suggesting the presence of a flagellin-specific effect. Lastly, we found that TLR5- and MyD88-mediated signaling was required for the protective effects of flagellin, whereas neither lymphoid cells nor IL-22 was involved.


  • 주제어

    interleukin-22 .   TLR5 .   Yersinia pseudotuberculosis .   flagellin .   intestine .   mouse infection .   Toll-like receptors.  

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