본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

The Journal of antimicrobial chemotherapy v.72 no.2, 2017년, pp.582 - 588   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Community carriage of ESBL-producing Escherichia coli is associated with strains of low pathogenicity: a Swedish nationwide study

Ny, Sofia (Public Health Agency of Sweden, Stockholm, Sweden ); Lofmark, Sonja (Public Health Agency of Sweden, Stockholm, Sweden ); Borjesson, Stefan (National Veterinary Institute, Uppsala, Sweden ); Englund, Stina (National Veterinary Institute, Uppsala, Sweden ); Ringman, Maj (Public Health Agency of Sweden, Stockholm, Sweden ); Bergstrom, Jakob (Public Health Agency of Sweden, Stockholm, Sweden ); Nauclér, Pontus (Infectious Disease Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden ); Giske, Christian G. (Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Stockholm, Sweden ); Byfors, Sara (Public Health Agency of Sweden, Stockholm, Sweden );
  • 초록  

    Objectives Community carriage of ESBL-producing Escherichia coli (EPE) is common worldwide and there is a need to understand the connection between carriage and infection. We compared the molecular characteristics of EPE among Swedish community carriers with those of EPE causing invasive infections. Methods We collected 2134 faecal samples from randomly selected Swedish inhabitants and examined them for the presence of EPE. All participating volunteers answered a questionnaire about putative risk factors for EPE carriage. Suspected EPE isolates ( n  = 418) from patients with bloodstream infection (BSI) were collected from Swedish laboratories. Isolates were genotypically and phenotypically characterized. Results Our results show that the EPE population found in carriers generally had lower pathogenicity compared with the isolates from BSIs, since carriers had a lower proportion of E. coli belonging to phylogroup B2, ST131 and ST131 subclone H30-Rx. Isolates from carriers also had lower levels of multiresistance. The Swedish carriage rate of EPE was 4.7% (101/2134) among healthy volunteers. Risk factors associated with carriage were travel to countries in Asia (OR = 3.6, 95% CI = 1.4–9.2) and Africa (OR = 3.6, 95% CI = 1.7–7.7) and a diet without pork (OR = 0.5, 95% CI = 0.3–0.8 for pork eaters). Conclusions E. coli host factors previously associated with higher pathogenicity were all more common in BSIs compared with carriers. This indicates that the risk of invasive infection with EPE may be relatively modest in many community carriers and that EPE carriage of high-risk strains should be the focus of attention for prevention.


 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기