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The Journal of antimicrobial chemotherapy v.72 no.2, 2017년, pp.529 - 534   SCI SCIE
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Efficacy and safety of 3 day versus 7 day cefditoren pivoxil regimens for acute uncomplicated cystitis: multicentre, randomized, open-label trial

Sadahira, Takuya Wada, Koichiro Araki, Motoo Ishii, Ayano Takamoto, Atsushi Kobayashi, Yasuyuki Watanabe, Masami Watanabe, Toyohiko Nasu, Yasutomo Kumon, Hiromi Nasu, Yasutomo Akaeda, Teruaki Akazawa, Nobuyuki Akebi, Naoki Araki, Daiji Araki, Tohru Araki, Motoo Arata, Ryoji Ariyoshi, Yuichi Ando, Eiichi Ando, Nobuyoshi Ishii, Ayano Ishii, Kazushi Ishikawa, Tsutomu Ishito, Noritaka Ichikawa, Takaharu Inoue, Takaaki Inoue, Miyabi Inoue, Yosuke Irie, Shin Iwata, Takehiro Uesugi, Tatsuya Uehara, Shinya Uematsu, Katsutoshi Uno, Satoshi Edamura, Kohei Ebara, Shin Oiwa, Yuko Oeda, Tadashi Ohashi, Teruhisa Ohashi, Yozo Ozawa, Hideo Ochi, Junzo Ono, Noriaki Kai, Seiji Kaku, Haruki Katayama, Satoshi Katayama, Yasuhiro Kaneshige, Tetuzo Kawauchi, Keiichiro Kawaguchi, Masashi Kawada, Tatsushi Kanbara, Taiki Kishi, Mikio Kishimoto, Ryo Kusaka, Nobuyuki Kusumi, Norihiro Kunitomi, Kimito
  • 초록  

    Background Fluoroquinolone-non-susceptible Escherichia coli isolated from patients with acute uncomplicated cystitis are a matter of increasing concern. Cefditoren pivoxil is an oral, β-lactamase-stable, extended-spectrum cephalosporin that is effective against fluoroquinolone-non-susceptible bacteria. Objectives To evaluate the clinical and microbiological efficacies of cefditoren pivoxil against acute uncomplicated cystitis and to determine the optimal duration of cefditoren pivoxil treatment. Methods We compared 3 and 7 day regimens of cefditoren pivoxil in a multicentre, randomized, open-label study. Results A total of 104 female patients with acute uncomplicated cystitis were enrolled and randomized into 3 day ( n  =   51) or 7 day ( n  =   53) treatment groups. At first visit, 94 bacterial strains were isolated from the 104 participants of which 81.7% (85/104) were E. coli . Clinical and microbiological efficacies were evaluated 5–9 days following administration of the final dose of cefditoren pivoxil. The clinical efficacies of the 3 and 7 day groups were 90.9% (40/44) and 93.2% (41/44), respectively ( P  =<I>   1.000). The microbiological efficacies of the 3 and 7 day groups were 82.5% (33/40) and 90.2% (37/41), respectively ( P  =<I>   0.349). There were no adverse events due to cefditoren pivoxil treatment, with the exception of a mild allergic reaction in one patient, after which the cefditoren pivoxil was exchanged for another antimicrobial. Conclusions Cefditoren pivoxil is safe and effective for uncomplicated cystitis, with no significant differences in clinical and microbiological efficacies between 3 and 7 day regimens.


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