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The Journal of biological chemistry v.292 no.4, 2017년, pp.1351 - 1360   SCI SCIE
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DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle

Zhang, Boyan (From the Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education and the State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871 and ); Wang, Gang ( From the Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education and the State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871 and ); Xu, Xiaowei ( From the Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education and the State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871 and ); Yang, Sisi ( From the Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education and the State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing 100871 and ); Zhuang, Tenghan ( From the Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education and the State Key Laboratory of Membrane Biology, College of ); Wang, Guopeng ( ); Ren, He ( ); Cheng, Steven Y. ( ); Jiang, Qing ( ); Zhang, Chuanmao ( );
  • 초록  

    The function of the primary cilia, which is assembled in most vertebrate cells, is achieved by transport in and out of kinds of signaling receptors. The BBSome protein complex could recognize and target membrane proteins to the cilia, but how the BBSome itself is transported into the cilia is poorly understood. Here we demonstrate that the centrosome protein Dzip1 mediates the assembly of the BBSome-Dzip1-PCM1 complex in the centriolar satellites (CS) at the G 0 phase for ciliary translocation of the BBSome. Phosphorylation of Dzip1 at Ser-210 by Plk1 (polo-like kinase 1) during the G 2 phase promotes disassembly of this complex, resulting in removal of Dzip1 and the BBSome from the CS. Inhibiting the kinase activity of Plk1 maintains the CS localization of the BBSome and Dzip1 at the G 2 phase. Collectively, our findings reveal the cell cycle-dependent regulation of BBSome transport to the CS and highlight a potential mechanism that the BBSome-mediated signaling pathways are accordingly regulated during the cell cycle.


  • 주제어

    cell cycle .   centrosome .   primary cilium .   protein phosphorylation .   protein translocation .   serine/threonine protein kinase.  

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