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Journal of clinical microbiology v.55 no.2, 2017년, pp.423 - 430   SCI SCIE
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Progress in Quantitative Viral Load Testing: Variability and Impact of the WHO Quantitative International Standards

Hayden, R. T. (Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA ) ; Sun, Y. (Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA ) ; Tang, L. (Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA ) ; Procop, G. W. (Department of Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio, USA ) ; Hillyard, D. R. (Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA ) ; Pinsky, B. A. (Departments of Pathology and Medicine, Stanford University School of Medicine, Stanford, California, USA ) ; Young, S. A. (Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA ) ; Caliendo, A. M. (Department of Medicine, Alpert Medical School of Brown University, Providence, Rhode Island, USA ) ;
  • 초록  

    It has been hoped that the recent availability of WHO quantitative standards would improve interlaboratory agreement for viral load testing; however, insufficient data are available to evaluate whether this has been the case. Results from 554 laboratories participating in proficiency testing surveys for quantitative PCR assays of cytomegalovirus (CMV), Epstein-Barr virus (EBV), BK virus (BKV), adenovirus (ADV), and human herpesvirus 6 (HHV6) were evaluated to determine overall result variability and then were stratified by assay manufacturer. The impact of calibration to international units/ml (CMV and EBV) on variability was also determined. Viral loads showed a high degree of interlaboratory variability for all tested viruses, with interquartile ranges as high as 1.46 log 10 copies/ml and the overall range for a given sample up to 5.66 log 10 copies/ml. Some improvement in result variability was seen when international units were adopted. This was particularly the case for EBV viral load results. Variability in viral load results remains a challenge across all viruses tested here; introduction of international quantitative standards may help reduce variability and does so more or less markedly for certain viruses.


  • 주제어

    PCR .   viral load .   variability .   quantitative .   calibration .   WHO.  

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