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The journal of immunology : official journal of the American Association of Immunologists v.197 no.7, 2016년, pp.2936 - 2947   SCI SCIE
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IgG Binding Characteristics of Rhesus Macaque FcγR

Chan, Ying N. (Thayer School of Engineering, Dartmouth College, Hanover, NH 03755 ); Boesch, Austin W. (Thayer School of Engineering, Dartmouth College, Hanover, NH 03755 ); Osei-Owusu, Nana Y. (Molecular and Cellular Biology Program, Dartmouth College, Hanover, NH 03755 ); Emileh, Ali (Thayer School of Engineering, Dartmouth College, Hanover, NH 03755 ); Crowley, Andrew R. (Molecular and Cellular Biology Program, Dartmouth College, Hanover, NH 03755 ); Cocklin, Sarah L. (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115 ); Finstad, Samantha L. (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115 ); Linde, Caitlyn H. (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115 ); Howell, Rebecca A. (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115 ); Zentner, Isaac (Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102 ); Cocklin, Simon (Department of Bioch ); Miles, Adam R. ( ); Eckman, Joshua W. ( ); Alter, Galit ( ); Schmitz, Joern E. ( ); Ackerman, Margaret E. ( );
  • 초록  

    Indian rhesus macaques ( Macaca mulatta ) are routinely used in preclinical studies to evaluate therapeutic Abs and candidate vaccines. The efficacy of these interventions in many cases is known to rely heavily on the ability of Abs to interact with a set of Ab FcγR expressed on innate immune cells. Yet, despite their presumed functional importance, M. mulatta Ab receptors are largely uncharacterized, posing a fundamental limit to ensuring accurate interpretation and translation of results from studies in this model. In this article, we describe the binding characteristics of the most prevalent allotypic variants of M. mulatta FcγR for binding to both human and M. mulatta IgG of varying subclasses. The resulting determination of the affinity, specificity, and glycan sensitivity of these receptors promises to be useful in designing and evaluating studies of candidate vaccines and therapeutic Abs in this key animal model and exposes significant evolutionary divergence between humans and macaques.


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