Allergic Sensitization Underlies Hyperreactive Antigen-Specific CD4+ T Cell Responses in Coincident Filarial Infection
Among the various hypotheses put forward to explain the modulatory influence of helminth infection on allergic effector responses in humans, the IL-10–induced suppression of Th2-associated responses has been the leading candidate. To explore this helminth/allergy interaction more fully, parasite- and allergen-specific CD4 + T cell responses in 12 subjects with filarial infections, and coincident allergic sensitization (filarial [Fil] + allergy [A] + ) were compared with the responses to three appropriate control groups (Fil − A − [ n = 13], Fil − A + [ n = 12], Fil + A − [ n = 11]). The most important findings revealed that Fil + A + had marked ( p < 0.0001 for all cytokines) increases in parasite Ag-driven Th2 (IL-4, IL-5, IL-13), Th9 (IL-9), and the regulatory (IL-10) cytokines when compared with Fil + A − . Moreover, using multiparameter flow cytometry, filarial parasite Ag induced a marked increase in not only the frequency of CD4 + T cells producing IL-4, IL-5, IL-2, and TNF-α in Fil + A + when compared with Fil + A − patients, but also in the frequencies of polyfunctional Th2-like (CD4 + IL-4 + IL-5 + and CD4 + IL-2 + IL-4 + IL-5 + TNF-α + ) cells. The Th2-associated responses seen in the Fil + A + group were correlated with serum IgE levels ( p < 0.01, r = 0.5165 for IL-4; p < 0.001, r = 0.5544 for IL-5; and p < 0.001, r = 0.4901 for IL-13) and levels of circulating eosinophils ( p < 0.0116, r = 0.5656) and their degranulation/activation products (major basic protein [ p < 0.001, r = 0.7353] and eosinophil-derived neurotoxin [ p < 0.01, r = 0.7059]). CD4 + responses to allergen were not different (to a large extent) among the groups. Taken together, our data suggest that allergic sensitization coincident with filarial infection drives parasite Ag-specific T cell hyperresponsiveness, which is characterized largely by an augmented Th2-dominated immune response.
- 원문이 없습니다.
유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.
NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.
- 이 논문과 함께 출판된 논문 + 더보기