본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

The journal of immunology : official journal of the American Association of Immunologists v.198 no.3, 2017년, pp.1320 - 1333   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

IL-15 Enables Septic Shock by Maintaining NK Cell Integrity and Function

Guo, Yin (Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37212 ); Luan, Liming (and ); Patil, Naeem K. (Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232 ); Wang, Jingbin (Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232 ); Bohannon, Julia K. (Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232 ); Rabacal, Whitney (Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232 ); Fensterheim, Benjamin A. (Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37212 ); Hernandez, Antonio (and ); Sherwood, Edward R. (Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37212 );
  • 초록  

    Interleukin 15 is essential for the development and differentiation of NK and memory CD8 + (mCD8 + ) T cells. Our laboratory previously showed that NK and CD8 + T lymphocytes facilitate the pathobiology of septic shock. However, factors that regulate NK and CD8 + T lymphocyte functions during sepsis are not well characterized. We hypothesized that IL-15 promotes the pathogenesis of sepsis by maintaining NK and mCD8 + T cell integrity. To test our hypothesis, the pathogenesis of sepsis was assessed in IL-15–deficient (IL-15 knockout, KO) mice. IL-15 KO mice showed improved survival, attenuated hypothermia, and less proinflammatory cytokine production during septic shock caused by cecal ligation and puncture or endotoxin-induced shock. Treatment with IL-15 superagonist (IL-15 SA, IL-15/IL-15Rα complex) regenerated NK and mCD8 + T cells and re-established mortality of IL-15 KO mice during septic shock. Preventing NK cell regeneration attenuated the restoration of mortality caused by IL-15 SA. If given immediately prior to septic challenge, IL-15–neutralizing IgG M96 failed to protect against septic shock. However, M96 caused NK cell depletion if given 4 d prior to septic challenge and conferred protection. IL-15 SA treatment amplified endotoxin shock, which was prevented by NK cell or IFN-γ depletion. IL-15 SA treatment also exacerbated septic shock caused by cecal ligation and puncture when given after the onset of sepsis. In conclusion, endogenous IL-15 does not directly augment the pathogenesis of sepsis but enables the development of septic shock by maintaining NK cell numbers and integrity. Exogenous IL-15 exacerbates the severity of sepsis by activating NK cells and facilitating IFN-γ production.


 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기