The Caudate Nucleus Mediates Learning of Stimulus–Control State Associations
A longstanding dichotomy in cognitive psychology and neuroscience pits controlled, top-down driven behavior against associative, bottom-up driven behavior, where cognitive control processes allow us to override well-learned stimulus–response (S–R) associations. By contrast, some previous studies have raised the intriguing possibility of an integration between associative and controlled processing in the form of stimulus–control state (S–C) associations, the learned linkage of specific stimuli to particular control states, such as high attentional selectivity. The neural machinery mediating S–C learning remains poorly understood, however. Here, we combined human functional magnetic resonance imaging (fMRI) with a previously developed Stroop protocol that allowed us to dissociate reductions in Stroop interference based on S–R learning from those based on S–C learning. We modeled subjects' acquisition of S–C and S–R associations using an associative learning model and then used trial-by-trial S–C and S–R prediction error (PE) estimates in model-based behavioral and fMRI analyses. We found that PE estimates derived from S–C and S–R associations accounted for the reductions in behavioral Stroop interference effects in the S–C and S–R learning conditions, respectively. Moreover, model-based fMRI analyses identified the caudate nucleus as the key structure involved in selectively updating stimulus–control state associations. Complementary analyses also revealed a greater reliance on parietal cortex when using the learned S–R versus S–C associations to minimize Stroop interference. These results support the emerging view that generalizable control states can become associated with specific bottom-up cues, and they place the caudate nucleus of the dorsal striatum at the center of the neural stimulus–control learning machinery. SIGNIFICANCE STATEMENT Previous behavioral studies have demonstrated that control states, for instance, heightened attentional selectivity, can become directly associated with, and subsequently retrieved by, particular stimuli, thus breaking down the traditional dichotomy between top-down and bottom-up driven behavior. However, the neural mechanisms underlying this type of stimulus–control learning remain poorly understood. We therefore combined noninvasive human neuroimaging with a task that allowed us to dissociate the acquisition of stimulus–control associations from that of stimulus–response associations. The results revealed the caudate nucleus as the key brain structure involved in selectively driving stimulus–control learning. These data represent the first identification of the neural mechanisms of stimulus-specific control associations, and they significantly extend current conceptions of the type of learning processes mediated by the caudate.
- DOI : http://dx.doi.org/10.1523/JNEUROSCI.0778-16.2017
- Society for Neuroscience : 저널> 권호 > http://www.jneurosci.org/content/37/4/1028.abstract
- 원문이 없습니다.
유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.
원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.
NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.
- 이 논문과 함께 출판된 논문 + 더보기