본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Proceedings of the National Academy of Sciences of the United States of America v.114 no.4, 2017년, pp.776 - 781   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

CRYPTOCHROME mediates behavioral executive choice in response to UV light

Baik, Lisa S. (Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697 ) ; Fogle, Keri J. (Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697 ) ; Roberts, Logan (Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697 ) ; Galschiodt, Alexis M. (Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697 ) ; Chevez, Joshua A. (Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697 ) ; Recinos, Yocelyn (Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697 ) ; Nguy, Vinh (Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697 ) ; Holmes, Todd C. (Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697 ) ;
  • 초록  

    Significance Many animals exhibit behavioral responses to UV light, including harmful insects. Recently, the explosive spread of diseases carried by mosquitoes has increased motivation to better understand insect UV phototransduction. CRYPTOCHROME (CRY) is a highly conserved nonopsin photoreceptor expressed in a small number of brain circadian and arousal neurons in Drosophila melanogaster that mediates cell-autonomous electrophysiological membrane excitability in response to UV light. CRY signaling modulates multiple fly behaviors evoked by UV light, including acute nighttime arousal responses to light flashes and phototaxis toward low-intensity UV light. Loss of CRY or the redox sensor HYPERKINETIC (HK) leads to the loss of ability to avoid high-intensity UV light; thus, CRY signaling exhibits novel features of behavioral executive choice. Drosophila melanogaster CRYPTOCHROME (CRY) mediates behavioral and electrophysiological responses to blue light coded by circadian and arousal neurons. However, spectroscopic and biochemical assays of heterologously expressed CRY suggest that CRY may mediate functional responses to UV-A (ultraviolet A) light as well. To determine the relative contributions of distinct phototransduction systems, we tested mutants lacking CRY and mutants with disrupted opsin-based phototransduction for behavioral and electrophysiological responses to UV light. CRY and opsin-based external photoreceptor systems cooperate for UV light-evoked acute responses. CRY mediates behavioral avoidance responses related to executive choice, consistent with its expression in central brain neurons.


  • 주제어

    cryptochrome .   phototransduction .   UV .   neural decision making .   Drosophila.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기