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Acta tropica v.167, 2017년, pp.9 - 17   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Mapping of Schistosoma mansoni in the Nile Delta, Egypt: Assessment of the prevalence by the circulating cathodic antigen urine assay

Haggag, Ayat A. (Ministry of Health and Population, Cairo, Egypt ); Rabiee, Amal (Ministry of Health and Population, Cairo, Egypt ); Abd Elaziz, Khaled M. (Department of Community, Environmental, and Occupational Medicine, Faculty of Medicine, Ain Shams University, Egypt ); Gabrielli, Albis F. (Regional Advisor for Neglected Tropical Diseases, Department of Communicable Disease Prevention and Control, WHO/EMRO, Cairo, Egypt ); Abdel Hay, Rehab (Department of Public Health, Faculty of Medicine, Cairo University, Egypt ); Ramzy, Reda M.R. (National Nutrition Institute, General Organisation for Teaching Hospitals and Institutes, Cairo, Egypt );
  • 초록  

    Abstract In line with WHO recommendations on elimination of schistosomiasis, accurate identification of all areas of residual transmission is a key step to design and implement measures aimed at interrupting transmission in low-endemic settings. To this purpose, we assessed the prevalence of active S. mansoni infection in five pilot governorates in the Nile Delta of Egypt by examining schoolchildren (6–15 years) using the Urine-Circulating Cathodic Antigen (Urine-CCA) cassette test; we also carried out the standard Kato-Katz (KK) thick smear, the monitoring and evaluation tool employed by Egypt’s national schistosomiasis control programme. Prevalence rates determined by the Urine-CCA test for all governorates were higher than those determined by KK (p S. mansoni infection was detected in 19 districts (54.3%) using KK, and in 31 districts (88.6%) by Urine-CCA (χ2=9.94; P=0.0016). S. mansoni infections were detected by Urine-CCA, but not by KK in 12 districts (34.3%), and infection was not detected by either of the two diagnostic methods in four districts in Qalyubia governorate. Males and higher age-groups have significantly higher Urine-CCA prevalence rates. Based on the findings of the current S. mansoni mapping exercise, authorities of the Ministry of Health and Population (MoHP) adopted a new elimination strategy by readjusting thresholds for mass treatment with praziquantel and targeting all transmission areas. MoHP is now planning to remap in all other endemic governorates using Urine-CCA with the aim of identifying all areas of transmission where the elimination strategy should be applied. Highlights The Urine-CCA prevalence rates in the studied governorates were significantly higher than those determined by Kato-Katz. Approximately 10% of the Urine-CCA positive samples were scored 3+, 40% 1+ and 50% trace. This work added information on the performance of the Urine-CCA test in settings characterized by very low or no (0%) prevalence by KK. Graphical abstract [DISPLAY OMISSION]


  • 주제어

    Urine-CCA .   Kato-Katz .   S.   mansoni .   Mapping .   Elimination .   Egypt.  

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