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Acta tropica v.167, 2017년, pp.40 - 49   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Myocarditis in different experimental models infected by Trypanosoma cruzi is correlated with the production of IgG1 isotype

Caldas, Ivo Santana (Laboratório de Doenças Parasitárias, Escola de Medicina, Departamento de Ciências Biológicas & Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto, Campus Universitário, Morro do Cruzeiro, Ouro Preto, MG, Brazil ); Diniz, Livia de Figueiredo (Instituto de Ciências Biomédicas, Departamento de Patologia e Parasitologia Básica, Universidade Federal de Alfenas, Alfenas, MG, 37130-001, Brazil ); Guedes, Paulo Marcos da Matta (Departamento de Microbiologia e Parasitologia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil ); Nascimento, Álvaro Fernando da Silva do (Laboratório de Doenças Parasitárias, Escola de Medicina, Departamento de Ciências Biológicas & Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto, Campus Universitário, Morro do Cruzeiro, Ouro Preto, MG, Brazil ); Galvão, Lúcia Maria da Cunha (Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais ); Lima, Wanderson Geraldo de ( ); Caldas, Sérgio ( ); Bahia, Maria Terezinha ( );
  • 초록  

    Abstract This study was designed to verify the relationship between IgG antibodies isotypes and myocarditis in Trypanosoma cruzi infection using mice and dogs infected with different T. cruzi strains. The animals were infected with benznidazole-susceptible Berenice-78 and benznidazole-resistant AAS and VL-10 strains. The IgG subtypes were measured in serum samples from dogs (IgG, IgG1, and IgG2) and mice (IgG, IgG1, IgG2a, and IgG2b). The infection of dogs with VL-10 strain induced the highest levels of heart inflammation while intermediate and lower levels were detected with Berenice-78 and AAS strains, respectively. Similar results were found in mice infected with VL-10, but not in those infected with AAS or Berenice-78 strains. The AAS strain induced higher levels of heart inflammation in mice, while Berenice-78 strain was not able to induce it. Correlation analysis between myocarditis and antibody reactivity index revealed very interesting results, mainly for IgG and IgG1, the latter being the most exciting. High IgG1 showed a significant correlation with myocarditis in both experimental models, being more significant in dogs (r=0.94, p Highlights High IgG1 showed a significant correlation with myocarditis in both experimental models. IgG1 could be a good marker to demonstrate myocarditis intensity in Chagas disease. Different parasite strains are able to induce similar infectivity in different hosts. Different experimental models may respond differently to Trypanosoma cruzi . Graphical abstract IgG1 could be a good marker to demonstrate myocarditis intensity in Chagas disease using mice and dogs infected with different T. cruzi straints. [DISPLAY OMISSION]


  • 주제어

    Trypanosoma cruzi .   Chagas disease .   Immunopathogenesis .   IgG1 .   Myocarditis.  

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