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Acta tropica v.167, 2017년, pp.128 - 136   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Interruption of the transmission of Onchocerca volvulus in the Kashoya-Kitomi focus, western Uganda by long-term ivermectin treatment and elimination of the vector Simulium neavei by larviciding

Lakwo, T. (Vector Control Division, Ministry of Health, P.O. Box 1661, Kampala, Uganda ); Garms, R. ( Bernhard Nocht Institute for Tropical Medicine, P.O. Box 304120, D-20324 Hamburg, Germany ); Wamani, J. ( Kamwenge District Local Government, P.O. Box 1408, Kamwenge, Uganda ); Tukahebwa, E.M. ( Vector Control Division, Ministry of Health, P.O. Box 1661, Kampala, Uganda ); Byamukama, E. ( Buhweju District Local Government, P.O. Box 10, Kabwohe, Uganda ); Onapa, A.W. ( Envision/RTI- Neglected Tropical Diseases Control Programme, Kampala, Uganda ); Tukesiga, E. ( Kabarole District Local Government, P.O. Box 38, Fort Portal, Uganda ); Katamanywa, J. ( Kyenjojo District Local Government, Medical Department, P.O. Box 1002, Kyenjojo, Uganda ); Begumisa, S. ( Rubirizi District Local Government, P.O. Box 239, Bushenyi, Uganda ); Habomugisha, P. ( The Carter Center, Uganda office, P.O. Box 12027, Kampala, Uganda ); Oguttu, D. ( Vector Control Division, Ministry of Health, P.O. Box 1661, Kampala, Uganda ); Byamukama, E. ( The Carter Center, Uganda office, P.O. Box 12027, Kampala, Uganda ); Richards, F. ( The Carter Center, One Copenhill, 453 Freedom Parkway, Atlanta, GA 30307, USA ); Unnasch, T.R. ( University of ); Katabarwa, M. ( );
  • 초록  

    Abstract Uganda is the only country in sub-Saharan Africa whose onchocerciasis elimination programme extensively uses vector control and biannual treatment with ivermectin. The purpose of this study was to assess the impact of combined strategies on interrupting onchocerciasis transmission in the Kashoya-Kitomi focus. Mass Drug Administration annually (13 years) followed by biannual treatments (6 years) and ground larviciding (36 cycles in 3 years) with temephos (Abate ? , EC500) against Simulium neavei were conducted. Routine fly catches were conducted for over seven years in six catching sites and freshwater crabs Potamonautes aloysiisabaudiae were examined for immature stages of Simulium neavei . Epidemiological assessments by skin snip were performed in 2004 and 2013. Collection of dry blood spots (DBS) from children Treatment coverage with ivermectin improved with introduction of biannual treatment strategy. Microfilaria prevalence reduced from 85% in 1991 to 62% in 2004; and to only 0.5% in 2013. Crab infestation reduced from 59% in 2007 to 0% in 2013 following ground larviciding. Comparison of total fly catches before and after ground larviciding revealed a drop from 5334 flies in 2007 to 0 flies in 2009. Serological assays conducted among 1,362 children in 2010 revealed 11 positive cases (0.8%; 95% CI: 0.4%–1.2%). However, assessment conducted on 3246 children in 2013 revealed five positives, giving point prevalence of 0.15%; 95% CI: 0.02%-0.28%. Four of the five children subjected to O-150 PCR proved negative. The data show that transmission of onchocerciasis has been interrupted based on national and WHO Guidelines of 2012 and 2016, respectively. Highlights We describe the effect of combining annual and bi-annual ivermectin treatment with ground larviciding using temephos (Abate ? EC500) against S. neavei in the interruption of onchocerciasis transmission. Epidemiological, entomological and serological assessments were performed. Significant reductions in mf prevalence, crab infestations and S. neavei adult catches were observed in the focus. Four IgG4 positive children subjected to O-150 PCR skin snip analysis were all negative. The data suggest that interruption of transmission of onchocerciasis has been achieved in the focus. Graphical abstract [DISPLAY OMISSION]


  • 주제어

    Interruption .   Long-term treatment .   Ivermectin .   S.   neavei .   Larviciding .   Onchocerca volvulus .   Uganda.  

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