Development of an experimental model of schistosomal myeloradiculopathy
Abstract Schistosomal myeloradiculopathy (SMR) is a severe form of presentation of schistosomiasis in which Schistosoma spp. affect the spinal cord. The aims of the present study were to develop an animal model of SMR caused by S. mansoni, to characterize both sensory and motor abnormalities in the infected animals, and to investigate the relationship of the sensory, motor and histological findings with the progression of the infection over time. Mechanical sensitivity and behavioral tests were performed followed by euthanasia in male Wistar rats divided into six groups of five animals each, on days 5, 10, 20 and 30 after infection of S. mansoni eggs. The controls were subjected to the same procedure but were administered phosphate-buffered saline (PBS). The spinal cord was removed and subjected to histological analysis. S. mansoni eggs were found in the spinal cord of 25% of the infected animals, which belonged to the groups that exhibited more significant reduction of the superficial mechanical sensitivity, thermal sensitivity and muscle strength. This model proved to be satisfactory to assess functional changes in Wistar rats and might be used in studies investigating the pathogenesis of SMR. To our knowledge, this is the first experimental model of SMR. Highlights This is the first animal model of schistosomal myeloradiculopathy. Shistosoma mansoni eggs were found in the spinal cord of 25% of the animals. The animals presented reduction of the superficial mechanical and thermal sensitivity. The animals presented decrease in muscle strength. Graphical abstract Schistosoma mansoni egg in a sagittal section of the spinal cord from an animal with schistosomal myeloradiculopathy. [DISPLAY OMISSION]
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- DOI : http://dx.doi.org/10.1016/j.actatropica.2016.12.028
- Elsevier : 저널> 권호 > 논문
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