Antiparasitic activity of menadione (vitamin K3) against Schistosoma mansoni in BABL/c mice
Abstract Schistosomiasis is one of the neglected tropical diseases affecting nearly quarter of a billion people in economically challenged tropical and subtropical countries of the world. Praziquantel (PZQ) is the only drug currently available to treat this parasitic disease in spite being ineffective against juvenile worms and concerns about developing resistance to treat reinfections. Our earlier in vitro viability studies demonstrated significant antiparasitic activity of menadione (MEN) (vitamin K 3 ) against Schistosoma mansoni adult worms. To gain insight into plausible mechanism of antischistosomal activity of MEN, its effect on superoxide anion levels in adult worms were studied in vitro which showed significant increases in both female and male worms. Further confirmation of the deleterious morphological changes in their teguments and organelles were obtained by ultrastructural analysis. Genotoxic and cytotoxic studies in male Swiss mice indicated that MEN was well tolerated at the oral dose of 500mg/kg using the criteria of MNPCE frequency and PCE/RBC ratio in the bone marrow of infected animals. The in vivo antiparasitic activity of MEN was conducted in female BALB/c mice infected with S. mansoni and significant reductions ( P P P S. mansoni infection in humans. Highlights LC 50 of menadione (MEN) against S. mansoni adult worms in vitro was 10.49±1.02μM at 24h. MEN induced alterations on tegument and organelles of S. mansoni adult worms in vitr o. MEN increased superoxide anion levels in S. mansoni adult worms in vitro . MEN reduced the number of worms and egg formation in S. mansoni -infected mice in vivo . Above effects of MEN compared reasonably well to currently used drug, praziquantel. Graphical abstract [DISPLAY OMISSION]
- 원문이 없습니다.
- DOI : http://dx.doi.org/10.1016/j.actatropica.2016.12.001
- Elsevier : 저널> 권호 > 논문
유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.
NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.
- 이 논문과 함께 출판된 논문 + 더보기