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International journal of medical microbiology : IJMM v.307 no.1, 2017년, pp.1 - 10   SCI SCIE
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The cell wall precursor lipid II acts as a molecular signal for the Ser/Thr kinase PknB of Staphylococcus aureus

Hardt, Patrick (Institute for Pharmaceutical Microbiology, University of Bonn, Bonn, Germany ) ; Engels, Ina (Institute for Pharmaceutical Microbiology, University of Bonn, Bonn, Germany ) ; Rausch, Marvin (Institute for Pharmaceutical Microbiology, University of Bonn, Bonn, Germany ) ; Gajdiss, Mike (Institute of Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany ) ; Ulm, Hannah (Institute for Pharmaceutical Microbiology, University of Bonn, Bonn, Germany ) ; Sass, Peter (Interfaculty Institute for Microbiology and Infection Medicine, Department for Microbial Bioactive Compounds, University of Tuebingen, Tuebingen, Germany ) ; Ohlsen, Knut (Institute for Molecular Infection Biology, University of Wuerzburg, Wuerzburg, Germany ) ; Sahl, Hans-Georg (German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Bonn, Germany ) ; Bierbaum, Gabriele (Institute of Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany ) ; Schneider, Tanja (Institute for Pharmaceutical Microbiology, University of Bonn, Bonn, Germany ) ; Grein, Fabian (Institute for Pharmaceutical Microbiology, University of Bonn, Bonn, Ger ) ;
  • 초록  

    Abstract The assembly of the bacterial cell wall requires synchronization of a multitude of biosynthetic machineries and regulatory networks. The eukaryotic-like serine/threonine kinase PknB has been implicated in coordinating cross-wall formation, autolysis and cell division in Staphylococcus aureu s. However, the signal molecule sensed by this kinase remained elusive so far. Here, we provide compelling biochemical evidence that PknB interacts with the ultimate cell wall precursor lipid II, triggering kinase activity. Moreover, we observed crosstalk of PknB with the two component system WalKR and identified the early cell division protein FtsZ as another PknB phosphorylation substrate in S. aureus. In agreement with the implied role in regulation of cell envelope metabolism, we found PknB to preferentially localize to the septum of S. aureus and the PASTA domains to be crucial for recruitment to this site. The data provide a model for the contribution of PknB to control cell wall metabolism and cell division.


  • 주제어

    Staphylococcus aureus .   Serine/threonine protein kinase .   Lipid II .   Cell division .   Phosphorylation.  

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