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International journal of medical microbiology : IJMM v.307 no.1, 2017년, pp.21 - 27   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Staphylococcus aureus from the German general population is highly diverse

Becker, Karsten (University Hospital Münster, Institute of Medical Microbiology, 48149 Münster, Germany ); Schaumburg, Frieder (University Hospital Münster, Institute of Medical Microbiology, 48149 Münster, Germany ); Fegeler, Christian (University Heilbronn, GECKO Institute of Medicine, Informatics and Economy, 74081 Heilbronn, Germany ); Friedrich, Alexander W. (University of Groningen, University Medical Center Groningen, Department of Medical Microbiology, 9700 Groningen, The Netherlands ); Köck, Robin (University Hospital Münster, Institute of Medical Microbiology, 48149 Münster, Germany );
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    Abstract Objectives This prospective cohort study evaluates colonization dynamics and molecular characteristics of methicillin-susceptible and – resistant Staphylococcus aureus (MSSA/MRSA) in a German general population. Methods Nasal swabs of 1878 non-hospitalized adults were screened for S. aureus . Participants were screened thrice in intervals of 6–8 months. Isolates were characterized by spa and agr typing, mecA and mecC possession, respectively, and PCRs targeting virulence factors. Results 40.9% of all participants carried S. aureus at least once while 0.7% of the participants carried MRSA (mainly spa t011). MSSA isolates (n=1359) were associated with 331 different spa types; t084 (7.7%), t091 (6.1%) and t012 (71, 5.2%) were predominant. Of 206 participants carrying S. aureus at all three sampling time points, 14.1% carried the same spa type continuously; 5.3% carried different spa types with similar repeat patterns, but 80.6% carried S. aureus with unrelated spa types. MSSA isolates frequently harboured genes encoding enterotoxins ( sec : 16.6%, seg : 63.1%, sei : 64.5%) and toxic shock syndrome toxin ( tst : 17.5%), but rarely Panton-Valentine leukocidin ( lukS -PV/ lukF -PV: 0.2%). Conclusions MSSA colonizing human nares in the community are clonally highly diverse. Among those constantly carrying S. aureus , clonal lineages changed over time. The proportion of persistent S. aureus carriers was lower than reported elsewhere.


  • 주제어

    Staphylococcus aureus .   MRSA .   Epidemiology .   Livestock .   Colonization .   CC398.  

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