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International journal of medical microbiology : IJMM v.307 no.1, 2017년, pp.21 - 27   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Staphylococcus aureus from the German general population is highly diverse

Becker, Karsten (University Hospital Mü ); Schaumburg, Frieder (nster, Institute of Medical Microbiology, 48149 Mü ); Fegeler, Christian (nster, Germany ); Friedrich, Alexander W. ( University Hospital Mü ); (nster, Institute of Medical Microbiology, 48149 Mü ); ck, Robin (nster, Germany );
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    Abstract Objectives This prospective cohort study evaluates colonization dynamics and molecular characteristics of methicillin-susceptible and – resistant Staphylococcus aureus (MSSA/MRSA) in a German general population. Methods Nasal swabs of 1878 non-hospitalized adults were screened for S. aureus . Participants were screened thrice in intervals of 6–8 months. Isolates were characterized by spa and agr typing, mecA and mecC possession, respectively, and PCRs targeting virulence factors. Results 40.9% of all participants carried S. aureus at least once while 0.7% of the participants carried MRSA (mainly spa t011). MSSA isolates (n=1359) were associated with 331 different spa types; t084 (7.7%), t091 (6.1%) and t012 (71, 5.2%) were predominant. Of 206 participants carrying S. aureus at all three sampling time points, 14.1% carried the same spa type continuously; 5.3% carried different spa types with similar repeat patterns, but 80.6% carried S. aureus with unrelated spa types. MSSA isolates frequently harboured genes encoding enterotoxins ( sec : 16.6%, seg : 63.1%, sei : 64.5%) and toxic shock syndrome toxin ( tst : 17.5%), but rarely Panton-Valentine leukocidin ( lukS -PV/ lukF -PV: 0.2%). Conclusions MSSA colonizing human nares in the community are clonally highly diverse. Among those constantly carrying S. aureus , clonal lineages changed over time. The proportion of persistent S. aureus carriers was lower than reported elsewhere.


  • 주제어

    Staphylococcus aureus .   MRSA .   Epidemiology .   Livestock .   Colonization .   CC398.  

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