Synthesis and biological activities of (E)-β-farnesene analogues containing 1,2,3-thiadiazole
In order to discover novel compounds with high-activity to control aphid, a series of novel (E)-β-farnesene analogues containing 1,2,3-thiadiazole were designed and synthesized, and their structures were confirmed by IR, 1 H NMR, 13 C NMR, and HRMS (ESI). The stability of representative compounds was studied by HPLC and 1 H NMR techniques. Repellent activity results indicated that compounds 8h and 8j displayed 60.3% and 62.0% repellent rates, respectively. The aphicidal bioassay results showed that most analogues exhibited considerable aphicidal activity against Myzus persicae. Especially, analogues 8l, 8s and 8t exhibited high activity with LC 50 values of 33.4μg/mL, 50.2μg/mL and 61.8μg/mL, respectively, which were higher than the lead compound (E)-β-farnesene, but lower than commercial insecticide pymetrozine with a LC 50 of 7.1μg/mL.
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