Anti-inflammatory sunscreen nanostructured lipid carrier formulations
Discoid lupus erythematosus is a condition of chronic inflammation of the skin which requires protection from ultraviolet radiations and prolonged treatment with topical corticosteroids. The aim of this study was to prepare semisolid nanostructured lipid carrier (NLC) formulations containing diflucortolone valerate (DFV) as a model corticosteroid drug and titanium dioxide (TiO 2 ) as an inorganic UV-filter in the same formulation. The NLC formulations were prepared by applying high shear homogenization and ultrasonication techniques using Precriol ? ATO5 or Tristearin ? as the solid lipids, Capryol(TM) or isopropyl myristate as the liquid lipids, Poloxamer ? 407 as a surfactant and Labrafil ? M1944CS as a lipid based surfactant. The incorporation of TiO 2 in the NLCs in concentration of 5% w/w was found to be the optimum concentration which enhances the intrinsic sun protection factor (SPF) of this carrier system and resulted in suitable sun protection values ranged from 4.94 to 21.27 with an acceptable spreadable consistency for the NLC formulation. Semi-solid NLC formulations were characterized by small particle size ranged from 180.8 to 255.1 nm before the addition of TiO 2 and the particle size reached 540.1 nm after addition of 5% TiO 2 . Incorporation of TiO 2 in NLC formulations leads to a synergistic photoprotection and increase patient compliance.
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