Brain delivery of baclofen as a hydrophilic drug by nanolipid carriers: Characteristics and pharmacokinetics evaluation
Formulation of baclofen in lipid-based nanoparticles may be helpful to overcome its difficulties in order to reach the site of action in the CNS. This study reports production, characterization and pharmacokinetics evaluation of baclofen loaded lipid nano-carriers. Lipid nano-carriers containing baclofen were prepared by using double emulsion solvent evaporation method and physicochemical characteristics of prepared nanoparticles were evaluated. The selected formulation was administered on rat model to be compared with an aqueous drug solution. Plasma and brain concentrations of drug and pharmacokinetics parameters were compared. Nanostructured lipid carriers (NLC) formulation showed better physicochemical properties than solid lipid nanoparticles (SLNs). Also, the formulation of baclofen by NLC increased the half-life of drug in plasma and brain up to 10 and 1.5 times respectively compared to the solution formulation. Results revealed a more significant and prolonged effect of baclofen-NLC in comparison with baclofen solution in both plasma and brain mediums that emphasize and prove theories on the formulation of hydrophilic drug in NLCs can be a solution for target drug delivery to the brain.
유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.
원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.
NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.
- 이 논문과 함께 출판된 논문 + 더보기