본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

The American journal of medicine v.130 no.2, 2017년, pp.198 - 206   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Predictors and Causes of Long-Term Mortality in Elderly Patients with Acute Venous Thromboembolism: A Prospective Cohort Study

Faller, Nicolas (Department of General Internal Medicine, Bern University Hospital, University of Bern, Switzerland ) ; Limacher, Andreas (Clinical Trials Unit Bern, Department of Clinical Research, and Institute of Social and Preventive Medicine, University of Bern, Switzerland ) ; Méan, Marie (Department of General Internal Medicine, Bern University Hospital, University of Bern, Switzerland ) ; Righini, Marc (Division of Angiology and Hemostasis, Geneva University Hospital, Switzerland ) ; Aschwanden, Markus (Division of Angiology, Basel University Hospital, Switzerland ) ; Beer, Jürg Hans (Department of Internal Medicine, Cantonal Hospital of Baden, Switzerland ) ; Frauchiger, Beat (Department of Internal Medicine, Cantonal Hospital of Frauenfeld, Switzerland ) ; Osterwalder, Josef (Department of Emergency Medicine, Cantonal Hospital of St Gallen, Switzerland ) ; Kucher, Nils (Division of Angiology, Bern University Hospital, Switzerland ) ; Lämmle, Bernhard (University Clinic of Hematology and Central Hematology Laboratory, Bern University Hospital, Switzerland ) ; Cornuz, Jacques (Department of Ambulatory Care and Community Medicine, Lausanne University Hospital, Switzerland ) ; Angelillo-Scherrer, Anne (Universi ) ; Matter, Christian M. ; Husmann, Marc ; Banyai, Martin ; Staub, Daniel ; Mazzolai, Lucia ; Hugli, Olivier ; Rodondi, Nicolas ; Aujesky, Drahomir ;
  • 초록  

    Abstract Background Long-term predictors and causes of death are understudied in elderly patients with acute venous thromboembolism. Methods We prospectively followed up 991 patients aged ≥65 years with acute venous thromboembolism in a multicenter Swiss cohort study. The primary outcome was overall mortality. We explored the association between patient baseline characteristics and mortality, adjusting for other baseline variables and periods of anticoagulation as a time-varying covariate. Causes of death over time were adjudicated by a blinded, independent committee. Results The median age was 75 years. During a median follow-up period of 30 months, 206 patients (21%) died. Independent predictors of overall mortality were age (hazard ratio [HR], 1.32; 95% confidence interval [CI], 1.05-1.65, per decade), active cancer (HR, 5.80; 95% CI, 4.22-7.97), systolic blood pressure 40 mg/L (HR, 1.88; 95% CI, 1.36-2.60), ultra-sensitive troponin >14 pg/mL (HR, 1.54; 95% CI, 1.06-2.25), and D-dimer >3000 ng/mL (HR, 1.45; 95% CI, 1.04-2.01). Cancer (34%), pulmonary embolism (18%), infection (17%), and bleeding (6%) were the most common causes of death. Conclusions Elderly patients with acute venous thromboembolism have a substantial long-term mortality, and several factors, including polypharmacy and a low physical activity level, are associated with long-term mortality. Cancer, pulmonary embolism, infections, and bleeding are the most common causes of death in the elderly with venous thromboembolism.


  • 주제어

    Cause of death .   Elderly .   Mortality .   Predictor .   Venous thromboembolism.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기