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The American journal of medicine v.130 no.2, 2017년, pp.229.e5 - 229.e13   SCI SCIE
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Association of Serum Magnesium on Mortality in Patients Admitted to the Intensive Cardiac Care Unit

Naksuk, Niyada (Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minn ) ; Hu, Tiffany (Mayo Medical School, Mayo Clinic College of Medicine, Rochester, Minn ) ; Krittanawong, Chayakrit (Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minn ) ; Thongprayoon, Charat (Department of Anesthesiology, Mayo Clinic, Rochester, Minn ) ; Sharma, Sunita (Division of Hospital Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, Minn ) ; Park, Jae Yoon (Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minn ) ; Rosenbaum, Andrew N. (Division of Cardiovascular Diseases, Lahey Hospital and Medical Center, Burlington, Mass ) ; Gaba, Prakriti (Mayo Medical School, Mayo Clinic College of Medicine, Rochester, Minn ) ; Killu, Ammar M. (Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minn ) ; Sugrue, Alan M. (Division of Cardiovascular Diseases, Lahey Hospital and Medical Center, Burlington, Mass ) ; Peeraphatdit, Thoetchai (Division of Internal Medicine, Department of Medicine Education, University of Minnesota Twin Cities, Minneapolis ) ; Herasevich, Vitaly (Department of Anesthesiology, Mayo ) ; Bell, Malcolm R. ; Brady, Peter A. ; Kapa, Suraj ; Asirvatham, Samuel J. ;
  • 초록  

    Abstract Background Although electrolyte disturbances may affect cardiac action potential, little is known about the association between serum magnesium and corrected QT (QTc) interval as well as clinical outcomes. Methods A consecutive 8498 patients admitted to the Mayo Clinic Hospital—Rochester cardiac care unit (CCU) from January 1, 2004 through December 31, 2013 with 2 or more documented serum magnesium levels, were studied to test the hypothesis that serum magnesium levels are associated with in-hospital mortality, sudden cardiac death, and QTc interval. Results Patients were 67 ± 15 years; 62.2% were male. The primary diagnoses for CCU admissions were acute myocardial infarction (50.7%) and acute decompensated heart failure (42.5%), respectively. Patients with higher magnesium levels were older, more likely male, and had lower glomerular filtration rates. After multivariate analyses adjusted for clinical characteristics including kidney disease and serum potassium, admission serum magnesium levels were not associated with QTc interval or sudden cardiac death. However, the admission magnesium levels ≥2.4 mg/dL were independently associated with an increase in mortality when compared with the reference level (2.0 to Conclusion This retrospective study unexpectedly observed no association between serum magnesium levels and QTc interval or sudden cardiac death. However, serum magnesium ≥2.4 mg/dL was an independent predictor of increased hospital morality among CCU patients.


  • 주제어

    Acquired long-QT syndrome .   Hypermagnesemia .   Hypomagnesemia .   Magnesium .   Mortality .   Ventricular arrhythmias .   Sudden cardiac death .   QTc interval.  

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