Impact of augmented renal clearance on enoxaparin therapy in critically ill patients
Background and aim of the work: Augmented renal clearance (ARC) was reported in critically ill patients. ARC was associated with poor patient outcome due to decreased effectiveness of drugs leading to treatment failure. The aim of this study is to find the possible impact of ARC on therapeutic action of enoxaparin measured by anti-factor Xa activity. Patients and methods: Fifty critically ill patients receiving enoxaparin prophylactic dose (40mg/day) were included in the study. Creatinine clearance was measured and patients were divided into two groups: normal kidney function group (group C) and augmented renal clearance group (group A). serum anti-factor Xa was measured at baseline, four hours, 12 h, and 24 h. Both groups were compared regarding demographic data, severity scores, kidney function, and anti-factor Xa activity. Results: Twenty patients (40%) showed ARC and thirty patients (60%) showed normal kidney function. Creatinine clearance was 214+/-6 in group A versus 112+/-11 in group C (P=0.001). Serum anti-factor Xa levels was similar in the two groups after four hours (0.2+/-0.07 vs. 0.2+/-0.05, P=1). Serum anti-Xa levels were significantly lower in group A compared to group C at 12 and 24 h (0.06+/-0.03 vs. 0.1+/-0.04, P=0.004), (0.01+/-0.01 vs. 0.05+/-0.01, P=0.001) respectively. Conclusion: ARC patients showed short activity of enoxaparin. This finding draws the attention towards dose adjustment in this type of patients.
- 원문이 없습니다.
유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.
NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.
- 이 논문과 함께 출판된 논문 + 더보기