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Psychoneuroendocrinology v.76, 2017년, pp.114 - 118  

Association between dehydroepiandrosterone-sulfate and attention in long-term survivors of childhood acute lymphoblastic leukemia treated with only chemotherapy

Cheung, Y.T. ; Chemaitilly, W. ; Mulrooney, D.A. ; Brinkman, T.M. ; Liu, W. ; Banerjee, P. ; Srivastava, D. ; Pui, C.H. ; Robison, L.L. ; Hudson, M.M. ; Krull, K.R. ;
  • 초록  

    Long-term survivors of childhood acute lymphoblastic leukemia (ALL) are at risk for neurocognitive impairment, as well as compromised hypothalamic-pituitary-adrenal (HPA) function. Dehydroepiandrosterone-sulfate (DHEAS) is an adrenal androgen commonly used as a marker of HPA function. In the general population, a low level of DHEAS has been associated with poorer cognition. At ≥2years post-treatment, we examined the association of DHEAS with attention outcomes in 35 male and 34 female long-term survivors of childhood ALL (mean[standard deviation] age at evaluation 14.5[4.7] years; 7.5[1.9] years post-diagnosis) who were treated with only chemotherapy and without prophylactic cranial irradiation. Male survivors with low-normal levels of DHEAS had worse performance than male survivors with high levels of DHEAS on multiple measures of attention (all P's


  • 주제어

    Attention .   Chemotherapy .   Childhood acute lymphoblastic leukemia .   Dehydroepiandrosterone sulphate .   Neurocognitive function.  

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