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Behavioural brain research v.321, 2017년, pp.69 - 78   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Assessment of mouse cognitive and anxiety-like behaviors and hippocampal inflammation following a repeated and intermittent paradoxical sleep deprivation procedure

Yin, Mengmei (Department of Neurology, The First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu 210029, China ) ; Chen, Yali (Jiangsu Province, Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, Jiangsu, China ) ; Zheng, Hui (Jiangsu Province, Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, Jiangsu, China ) ; Pu, Tinglin (Jiangsu Province, Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, Jiangsu, China ) ; Marshall, Charles (Department of Rehabilitation Sciences, University of Kentucky Center of Excellence in Rural Health, Hazard, KY, USA ) ; Wu, Ting (Department of Neurology, The First Affiliated Hospital of Nanjing Medical University Nanjing, Jiangsu 210029, China ) ; Xiao, Ming (Jiangsu Province, Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, Jiangsu, China ) ;
  • 초록  

    Abstract It has been reported that more than one fourth of the world’s population suffers from sleep problems. However, there is not a stable and reliable animal model to mimic the persistent and periodic features of sleep disorders, and correspondingly, the feasibility and effectiveness of repeated behavioral tests remains to be determined. In the present study, we repetitively, and intermittently, treated mice with 3days and 7days of paradoxical sleep deprivation (SD), using the modified multiple small-platforms-over-water method for 3 months. The behavioral results suggested that repeated open field and Y-maze tests are able to successfully detect anxiety-like behaviors and working memory dysfunction of the model mice. The Morris water maze test is not suitable for evaluating spatial learning ability following SD because the long-term utilization of the flower-pot method increases the familiarity of mice with the water environment. Moreover, neuroinflammation, microglial activation and neuronal apoptosis were observed in the hippocampus of model mice even recovery for 3 weeks later. This animal model and corresponding behavioral evaluation method will help to explore the pathogenesis and therapeutic strategies of chronic sleep disorders. Highlights A mouse model of intermittent and repetitive sleep deprivation has been established. The effects of paradoxical sleep deprivation on various behavioral tasks are examined. Neuroinflmmation and neuronal apoptosis endured for even 3 weeks after deprivation.


  • 주제어

    Animal model .   Behavioral test .   Neuroinflammation .   Sleep deprivation.  

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