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Behavioural brain research v.321, 2017년, pp.99 - 105   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Role of D2 dopamine receptors of the ventral pallidum in inhibitory avoidance learning

Lénárd, László (Institute of Physiology, Pécs University, Medical School, Pécs, Hungary ) ; Ollmann, Tamás (Institute of Physiology, Pécs University, Medical School, Pécs, Hungary ) ; László, Kristóf (Institute of Physiology, Pécs University, Medical School, Pécs, Hungary ) ; Kovács, Anita (Institute of Physiology, Pécs University, Medical School, Pécs, Hungary ) ; Gálosi, Rita (Institute of Physiology, Pécs University, Medical School, Pécs, Hungary ) ; Kállai, Veronika (Institute of Physiology, Pécs University, Medical School, Pécs, Hungary ) ; Attila, Tóth (Institute of Physiology, Pécs University, Medical School, Pécs, Hungary ) ; Kertes, Erika (Institute of Physiology, Pécs University, Medical School, Pécs, Hungary ) ; Zagoracz, Olga (Institute of Physiology, Pécs University, Medical School, Pécs, Hungary ) ; Karádi, Zoltán (Institute of Physiology, Pécs University, Medical School, Pécs, Hungary ) ; Péczely, László (Institute of Physiology, Pécs University, Medical School, Pécs, Hungary ) ;
  • 초록  

    Abstract In our present experiments, the role of D2 dopamine (DA) receptors of the ventral pallidum (VP) was investigated in one trial step-through inhibitory avoidance paradigm. Animals were shocked 3 times in the conditioning trial, with 0.5mA current for 1s. Subsequently bilateral microinjection of the D2 DA receptor agonist quinpirole was administered into the VP in three doses (0.1μg, 1.0μg or 5.0μg in 0.4μl saline). We also applied the D2 DA receptor antagonist sulpiride (0.4μg in 0.4μl saline) alone or 15min prior to the agonist treatment to elucidate whether the agonist effect was specific for the D2 DA receptors. Control animals received saline. In a supplementary experiment, it was also investigated whether application of the same conditioning method leads to the formation of short-term memory in the experimental animals. In the experiment with the D2 DA receptor agonist, only the 0.1μg quinpirole increased significantly the step-through latency during the test trials: retention was significant compared to the controls even 2 weeks after conditioning. The D2 DA receptor antagonist sulpiride pretreatment proved that the effect was due to the agonist induced activation of the D2 DA receptors of the VP. The supplementary experiment demonstrated that short-term memory is formed after conditioning in the experimental animals, supporting that the agonist enhanced memory consolidation in the first two experiments. Our results show that the activation of the D2 DA receptors in the VP facilitates memory consolidation as well as memory-retention in inhibitory avoidance paradigm. Highlights D2 dopamine receptor agonist quinpirole was microinjected into the ventral pallidum. The 0.1μg agonist enhances memory consolidation in inhibitory avoidance learning. The same dose increases memory retention even 2 weeks after conditioning. D2 dopamine receptor antagonist sulpiride pretreatment eliminates agonist’s effect. The ventral pallidal D2 dopamine receptor activation enhances learning processes.


  • 주제어

    Ventral pallidum .   Inhibitory avoidance learning .   Memory consolidation .   D2 dopamine receptors .   Quinpirole .   Sulpiride.  

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