본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Behavioural brain research v.321, 2017년, pp.113 - 122   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Testing the correlation between experimentally-induced hypothyroidism during pregnancy and autistic-like symptoms in the rat offspring

Melancia, Francesca (Department of Science, Section of Biomedical Sciences and Technologies, University “Roma Tre”, Viale G. Marconi 446, 00146 Rome, Italy ); Servadio, Michela (Department of Science, Section of Biomedical Sciences and Technologies, University “Roma Tre”, Viale G. Marconi 446, 00146 Rome, Italy ); Schiavi, Sara (Department of Science, Section of Biomedical Sciences and Technologies, University “Roma Tre”, Viale G. Marconi 446, 00146 Rome, Italy ); Campolongo, Patrizia (Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy ); Giusti-Paiva, Alexandre (Department of Science, Section of Biomedical Sciences and Technologies, University “Roma Tre”, Viale G. Marconi 446, 00146 Rome, Italy ); Trezza, Viviana (Department of Science, Section of Biomedical Sciences and Technologies, University “Roma Tre”, Viale G. Marconi 446, 00146 Rome, Italy );
  • 초록  

    Abstract Thyroid hormones are important for the development of the central nervous system. Since the fetal thyroid gland is not functioning until mid-gestation, transport of maternal thyroid hormones across the placenta is essential during the early phases of gestation. Maternal thyroid deficiency has been associated with a higher incidence of neurodevelopmental disorders in the newborns. The relationship between maternal hypothyroidism and the onset of autism spectrum disorders (ASD) in the offspring, however, is still debated. To address this issue, we used a validated animal model of prenatal hypothyroidism based on the administration of the thyroid peroxidase inhibitor methimazole (MMI, 0.02g/100ml in tap water) to rat dams from gestational day 9 up to delivery. The offspring was tested in behavioral tasks during infancy (PNDs 5, 9, 13) and adolescence (PND 35-40) to capture some of the core and associated symptoms of ASD. MMI-exposed pups were able to vocalize as controls when separated from the nest, and showed intact social discrimination abilities in the homing behavior test. At adolescence, the offspring from both sexes did not show an anxious-phenotype in the elevated plus maze and showed intact object recognition. However, MMI-exposed male rats showed increased novelty-directed exploratory behaviors: they solicited their partner to play more and showed more interest for novel rather than familiar objects compared to control rats. Our results show that prenatal MMI-induced hypothyroidism does not cause in the rat offspring behaviors that resemble core and associated ASD symptoms, like deficits in communication and social interaction and anxiety. Highlights We tested the association between maternal hypothyroidism and autism in the offspring. We used an experimental model based on methimazole (MMI) administration to rat dams. MMI-exposed rats had no deficits in communication, social interaction and anxiety. MMI-exposed rats showed increased novelty-directed exploratory behaviors.


  • 주제어

    Autism spectrum disorders .   Maternal hypothyroidism .   Rats .   Behavior .   Methimazole.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기