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Behavioural brain research v.321, 2017년, pp.137 - 147   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Dehydroepiandrosterone increases the number and dendrite maturation of doublecortin cells in the dentate gyrus of middle age male Wistar rats exposed to chronic mild stress

Herrera-Pérez, J.J. (Farmacología Conductual, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, C.P. 14370, México City, Mexico ); Martínez-Mota, L. (Farmacología Conductual, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, C.P. 14370, México City, Mexico ); Jiménez-Rubio, G. (Farmacología Conductual, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, C.P. 14370, México City, Mexico ); Ortiz-López, L. (Laboratorio de Neurogenesis, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría “Ram&oac ); Cabrera-Muñoz, E.A. ( ); Galindo-Sevilla, N. ( ); Zambrano, E. ( ); Hernández-Luis, F. ( ); Ramírez-Rodríguez, G.B. ( ); Flores-Ramos, M. ( );
  • 초록  

    Abstract Aging increases the vulnerability to stress and risk of developing depression. These changes have been related to a reduction of dehydroepiandrosterone (DHEA) levels, an adrenal steroid with anti-stress effects. Also, adult hippocampal neurogenesis decreases during aging and its alteration or impaired is related to the development of depression. Besides, it has been hypothesized that DHEA increases the formation of new neurons. However, it is unknown whether treatment with DHEA in aging may stimulate the dendrite maturation of newborn neurons and reversing depressive-like signs evoked by chronic stress exposure. Here aged male rats (14 months old) were subjected to a scheme of chronic mild stress (CMS) during six weeks, received a treatment with DHEA from the third week of CMS. Changes in body weight and sucrose preference (SP) were measured once a week. DHEA levels were measured in serum, identification of doublecortin-(DCX)-, BrdU- and BrdU/NeuN-labeled cells was done in the dentate gyrus of the hippocampus. CMS produced a gradual reduction in the body weight, but no changes in the SP were observed. Treatment enhanced levels of DHEA, but lack of recovery on body weight of stressed rats. Aging reduced the number of DCX-, BrdU- and BrdU/NeuN- cells but DHEA just significantly increased the number of DCX-cells in rats under CMS and controls, reaching levels of young non-stressed rats (used here as a reference of an optimal status of health). In rats under CMS, DHEA facilitated dendritic maturation of immature new neurons. Our results reveal that DHEA improves neural plasticity even in conditions of CMS in middle age rats. Thus, this hormone reverted the decrement of DCX-cells caused during normal aging. Highlights Neuroplastic changes induced by dehydroepiandrosterone in middle age male rats. Dehydroepiandrosterone increases DCX-cells. Dehydroepiandrosterone promotes dendrite complexity of DCX-cells.


  • 주제어

    Dehydroepiandrosterone .   Adult neurogenesis .   Chronic mild stress .   Middle age .   Aging .   Doublecortin.  

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