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Behavioural brain research v.321, 2017년, pp.170 - 175   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Differential effects of bihemispheric and unihemispheric transcranial direct current stimulation in young and elderly adults in verbal learning

Fiori, Valentina (IRCCS Fondazione Santa Lucia, Roma, Italy ); Nitsche, Michael (Department Psychology and Neurosciences, Leibniz Research Center for Working Environment and Human Factors, Dortmund, Germany ); Iasevoli, Luigi (IRCCS Fondazione Santa Lucia, Roma, Italy ); Cucuzza, Gabriella (Dipartimento di Studi Umanistici, Università ); Caltagirone, Carlo (Federico II, Napoli, Italy ); Marangolo, Paola (IRCCS Fondazione Santa Lucia, Roma, Italy );
  • 초록  

    Abstract For the past few years, the potential of transcranial direct current stimulation (tDCS) for the treatment of several pathologies has been investigated. In the language domain, several studies, in healthy and brain-damaged populations, have already shown that tDCS is effective in enhancing naming, repetition and semantic word generation. In those studies, different tDCS electrode configurations have been tested, however, a direct comparison between different montages in verbal learning has never been conducted. In this study, we aimed to explore the impact of bihemispheric and unihemispheric tDCS on verbal learning task performance in two groups (young vs. elderly). Fifteen healthy volunteers participated per group. Each participant received three stimulation conditions: unihemispheric anodal tDCS over the left temporal area, bihemispheric tDCS over the left (anodal) and right (cathodal) temporal areas and a sham condition. During active stimulation, tDCS (20min, 2mA) was applied while each participant learned twenty pseudowords (arbitrarily assigned to corresponding pictures). No significant differences were found between the three conditions for the young group with regard to accuracy and vocal reaction times. In contrast, in the elderly group, real stimulation improved performance compared to sham but bihemispheric tDCS was more efficient than unilateral stimulation. These results suggest that bihemispheric stimulation is more effective in improving language learning but this effect is age-dependent. The hypothesis is advanced that cortical changes in the course of aging might differentially impact on tDCS efficacy on behavioral performance. These data may also have implications for treatment of stroke patients with language impairment. Highlights For the first time, bi vs. unihemispheric tDCS effects in verbal learning are compared. Three stimulation conditions were used: unihemispheric, bihemispheric and sham. No significant differences were found in the young group. The elderly group was more accurate and faster in the bihemispheric condition. Bihemispheric tDCS is more effective but this effect is age-dependent.


  • 주제어

    Bihemispheric tDCS .   Unihemispheric tDCS .   Brain stimulation .   Verbal learning .   Age effects.  

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