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Peptides v.88, 2017년, pp.8 - 17   SCI SCIE
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The anti-tumor effects of the recombinant toxin protein rLj-RGD3 from Lampetra japonica on pancreatic carcinoma Panc-1 cells in nude mice

Wang, Yue (Department of Pharmacology, Dalian Medical University, Dalian, Liaoning Province 116044, China ); Zheng, Yuanyuan ( School of Life Sciences, Liaoning Normal University, Dalian, Liaoning Province 116029, China ); Tu, Zuoyu ( Department of Pharmacology, Dalian Medical University, Dalian, Liaoning Province 116044, China ); Dai, Yongguo ( Department of Pharmacology, Dalian Medical University, Dalian, Liaoning Province 116044, China ); Xu, Hong ( Department of Pharmacology, Dalian Medical University, Dalian, Liaoning Province 116044, China ); Lv, Li ( Department of Pharmacology, Dalian Medical University, Dalian, Liaoning Province 116044, China ); Wang, Jihong ( School of Life Sciences, Liaoning Normal University, Dalian, Liaoning Province 116029, China );
  • 초록  

    Abstract Recombinant Lampetra japonica RGD peptide (rLj-RGD3) is a soluble toxin protein with three RGD (Arg-Gly-Asp) motifs and a molecular weight of 13.5kDa. The aim of this study was to investigate the effects and mechanisms of rLj-RGD3 on tumor growth and survival in pancreatic carcinoma Panc-1 cell-bearing mice. A Panc-1 human pancreatic carcinoma-bearing nude mouse model was successfully generated, and the animals were treated with different doses of rLj-RGD3 for 3 weeks. The volume and weight of the subcutaneous tumors, the survival of the nude mice, histopathological changes, the intratumoral MVD, the number of apoptotic Panc-1 cells, and apoptosis-related proteins and gene expressions were determined. rLj-RGD3 significantly decreased the tumor volumes and weights, and the maximum tumor volume and weight IR values were 53.2% (p Highlights rLj-RGD3 is a new recombinant RGD-toxin protein with 3 RGD motifs and is secreted from the buccal glands of Lampetra japonica . rLj-RGD3 suppresses human pancreatic carcinoma Panc-1 cell-derived tumors in nude mice. rLj-RGD3 exhibits pro-apoptotic effects that are regulated by the intrinsic apoptotic pathway. The effect of rLj-RGD3 on anti-angiogenesis is mediated via the FAK/PI3K/Akt signaling pathway.


  • 주제어

    rLj-RGD3 .   Pancreatic carcinoma .   Panc-1 cells .   Anti-tumor .   Mice.  

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