The anti-tumor effects of the recombinant toxin protein rLj-RGD3 from Lampetra japonica on pancreatic carcinoma Panc-1 cells in nude mice
Abstract Recombinant Lampetra japonica RGD peptide (rLj-RGD3) is a soluble toxin protein with three RGD (Arg-Gly-Asp) motifs and a molecular weight of 13.5kDa. The aim of this study was to investigate the effects and mechanisms of rLj-RGD3 on tumor growth and survival in pancreatic carcinoma Panc-1 cell-bearing mice. A Panc-1 human pancreatic carcinoma-bearing nude mouse model was successfully generated, and the animals were treated with different doses of rLj-RGD3 for 3 weeks. The volume and weight of the subcutaneous tumors, the survival of the nude mice, histopathological changes, the intratumoral MVD, the number of apoptotic Panc-1 cells, and apoptosis-related proteins and gene expressions were determined. rLj-RGD3 significantly decreased the tumor volumes and weights, and the maximum tumor volume and weight IR values were 53.2% (p Highlights rLj-RGD3 is a new recombinant RGD-toxin protein with 3 RGD motifs and is secreted from the buccal glands of Lampetra japonica . rLj-RGD3 suppresses human pancreatic carcinoma Panc-1 cell-derived tumors in nude mice. rLj-RGD3 exhibits pro-apoptotic effects that are regulated by the intrinsic apoptotic pathway. The effect of rLj-RGD3 on anti-angiogenesis is mediated via the FAK/PI3K/Akt signaling pathway.
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