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Peptides v.88, 2017년, pp.18 - 31   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

In vivo digestomics of milk proteins in human milk and infant formula using a suckling rat pup model

Wada, Yasuaki (Department of Nutrition, University of California, Davis, One Shields Ave., Davis, CA 95616, USA ); Phinney, Brett S. (Genome Center Proteomics Core Facility, University of California, Davis, 451 E. Health Sciences Dr., Davis, CA 95616, USA ); Weber, Darren (Genome Center Proteomics Core Facility, University of California, Davis, 451 E. Health Sciences Dr., Davis, CA 95616, USA ); Lönnerdal, Bo (Department of Nutrition, University of California, Davis, One Shields Ave., Davis, CA 95616, USA );
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    Abstract Human milk is the optimal mode of infant feeding for the first several months of life, and infant formulas serve as an alternative when breast-feeding is not possible. Milk proteins have a balanced amino acid composition and some of them provide beneficial bioactivities in their intact forms. They also encrypt a variety of bioactive peptides, possibly contributing to infant health and growth. However, there is limited knowledge of how milk proteins are digested in the gastrointestinal tract and bioactive peptides are released in infants. A peptidomic analysis was conducted to identify peptides released from milk proteins in human milk and infant formula, using a suckling rat pup model. Among the major milk proteins targeted, α-lactalbumin and β-casein in human milk, and β-lactoglobulin and β-casein in infant formula were the main sources of peptides, and these peptides covered large parts of the parental proteins’ sequences. Release of peptides was concentrated to specific regions, such as residues 70–92 of β-casein in human milk, residues 39–55 of β-lactoglobulin in infant formula, and residues 57–96 and 145–161 of β-CN in infant formula, where resistance to gastrointestinal digestion was suggested. In the context of bioactive peptides, release of fragments containing known bioactive peptides was confirmed, such as β-CN-derived opioid and antihypertensive peptides. It is therefore likely that these fragments are of biological significance in neonatal health and development. Highlights Suckling rat pups were intubated with human milk or infant formula, and milk protein-derived peptides formed in the intestine were analyzed. Release of peptides was concentrated to specific regions, suggesting their resistance to gastro intestinal digestion. Some of the bioactive peptides are likely of biological significance in neonatal health and development.


  • 주제어

    Human milk .   Infant formula .   Milk proteins .   Bioactive peptides .   Suckling rat pups.  

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