Increased FNDC5/Irisin expression in human hepatocellular carcinoma
Abstract The fibronectin type III domain containing 5 (FNDC5)/Irisin, a novel energy-regulating hormone, is associated with lipid and carbohydrate metabolism. It is produced in low amounts by normal hepatic tissue, while in human hepatocellular carcinoma (HCC), in which aberrant de novo lipogenesis (DNL) occurs, the hepatic expression of FNDC5/Irisin is still unknown. The gene expression of FNDC5/Irisin, associated to key regulators of DNL, inflammation and cancer progression was evaluated in liver tissue of 18 patients with HCC undergoing liver transplantation and of 18 deceased donors. Hepatic mRNA expression of FNDC5/Irisin and stearoyl-CoA desaturase (SCD-1), main enzymatic regulator of DNL, were significantly higher in HCC patients than in donors (p In conclusion, HCC-liver tissue over-expressed FNDC5/Irisin in association with gene expression of mediators involved in lipogenesis, inflammation and cancer, suggesting a possible protective role of the hormone from the liver damage. Highlights Hepatic expression of FNDC5/Irisin mRNA is highly expressed in patients with HCC. There is correlation between FNDC5/Irisin mRNA and key regulators of lipogenesis. There is correlation between FNDC5/Irisin mRNA and inflammatory markers. There is correlation between FNDC5/Irisin mRNA and the oncogene NOTCH1
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