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Forensic science international v.271, 2017년, pp.e1 - e7   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Mitragynine concentrations in two fatalities

Domingo, Olwen (Institute of Forensic Medicine, Department of Toxicology, University of Munich, 80336 Munich, Germany ) ; Roider, Gabriele (Institute of Forensic Medicine, Department of Toxicology, University of Munich, 80336 Munich, Germany ) ; Stöver, Andreas (Institute of Forensic Medicine, Department of Toxicology, University of Munich, 80336 Munich, Germany ) ; Graw, Matthias (Institute of Forensic Medicine, Department of Toxicology, University of Munich, 80336 Munich, Germany ) ; Musshoff, Frank (Forensic Toxicological Center (FTC), 80335 Munich, Germany ) ; Sachs, Hans (Forensic Toxicological Center (FTC), 80335 Munich, Germany ) ; Bicker, Wolfgang (FTC-Forensic-Toxicological Laboratory, 1120 Vienna, Austria ) ;
  • 초록  

    Abstract Two cases of fatalities are reported of which the recreational use of Mitragyna speciosa (“kratom”) could be confirmed. One of these cases presents with one of the highest postmortem mitragynine concentrations published to date. Our results show that even extremely high mitragynine blood concentrations following the consumption of kratom do not necessarily have to be the direct cause of death in such fatalities as a result of an acute overdose. The two cases are compared with regard to the differences in mitragynine concentrations detected and the role of mitragynine in the death of the subjects. Irrespective of the big differences in mitragynine concentrations in the postmortem blood samples, mitragynine was not the primary cause of death in either of the two cases reported here. Additionally, by rough estimation, a significant difference in ratio of mitragynine to its diastereomers in the blood and urine samples between the two cases could be seen. Highlights Two postmortem cases are compared with regard to the role of mitragynine in the fatalities. A significant difference could be seen in the absolute concentrations of mitragynine detected for the two cases. A significant difference could be seen in the relative concentrations of mitragynine to its diastereomers between the two cases. Mitragynine was not the direct cause of death in either of the two cases, despite an extremely high blood mitragynine concentration in one of the two.


  • 주제어

    Kratom .   Mitragynine .   Diastereomers .   “Legal high” .   Concentration dependent effects.  

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